Platelet-mediated pulmonary hypertension and hypoxia during pulmonary microembolism. Reduction by platelet inhibition

J. Mlczoch, A. Tucker, K. Weir, J. T. Reeves, R. F. Grover

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


The literature indicates that vasoactive substances released from platelets contribute to the pulmonary pressor response and hypoxemia during pulmonary microembolism. Hence, removal of the platelets or inhibition of their function should reduce these effects. The purpose of this study was, therefore, to investigate the pulmonary effects of experimental embolism with glass beads in dogs rendered thrombocytopenic with platelet antiserum and to compare these effects to the effects in dogs pretreated with sulfinpyrazone (Anturane) or heparin, both substances that affect the function of platelets, probably by inhibiting the release of platelets. In all three groups the pulmonary hypertension was reduced by more than half, and hypoxemia was lessened or abolished. The results of this study indicate the platelets contribute to the effects of pulmonary microembolism and that administration of sulfinpyrazone or heparin reduces the embolism-induced pulmonary hypertension to the same extent as the depletion of platelets. Platelet-inhibiting drugs might therefore be useful prophylactically in human pulmonary microembolism.

Original languageEnglish (US)
Pages (from-to)648-653
Number of pages6
JournalUnknown Journal
Issue number6
StatePublished - 1978
Externally publishedYes

Bibliographical note

Funding Information:
Recipient of a Max Kade Research Fellowship and an award from the Perkins Memorial Fund of the American Physiological Society.


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