Platelet factor 4: A chemokine enigma

Arne Slungaard

Research output: Contribution to journalShort surveypeer-review

74 Scopus citations


Platelet factor 4 (PF4) is a platelet α-granule protein sequenced over 25 years ago that is a founding member of the C-X-C chemokine family, yet its physiologic function has yet to be definitively established. Initial investigations focused on possible procoagulant roles for PF4 in platelet function and plasmatic coagulation. Subsequent in vitro studies have, however, described a puzzling array of other apparently unrelated biologic functions, including inhibition of angiogenesis and hematopoiesis, promotion of neutrophil adhesion, and activation, enhancement of oxy-LDL binding to the LDL receptor and stimulation of anti-coagulant activated protein C generation by the thrombomodulin/protein C system. Preliminary studies with a just-described PF4 knockout mouse line support a role for PF4 in platelet-dependent thrombosis in vivo.

Original languageEnglish (US)
Pages (from-to)1162-1167
Number of pages6
JournalInternational Journal of Biochemistry and Cell Biology
Issue number6
StatePublished - Jun 2005
Externally publishedYes


  • Platelet factor 4
  • Protein C
  • Thrombomodulin
  • Thrombosis


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