Platelet Dysfunction Diseases and Conditions: Clinical Implications and Considerations

Alan D. Kaye; George M. Jeha; Vanessa Moll; Ceressa T. Ward; Matthew R. Watson; John Thomas Wynn; Maxwell A. Hockstein; Kevin M. Hall; Omar Viswanath; Ivan Urits; Amit Prabhakar; Elyse M. Cornett

doi:10.1007/s12325-020-01453-4

Platelet Dysfunction Diseases and Conditions: Clinical Implications and Considerations

Alan D. Kaye, George M. Jeha, Vanessa Moll, Ceressa T. Ward, Matthew R. Watson, John Thomas Wynn, Maxwell A. Hockstein, Kevin M. Hall, Omar Viswanath, Ivan Urits, Amit Prabhakar, Elyse M. Cornett

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Introduction: Platelet diseases and dysfunction are taught early in medical school to all future physicians. Understanding of the coagulation cascade and hemostatic mechanisms has allowed for targeted pharmacological therapies that have been significantly impactful in clinical practice. Platelets are an early participant in hemostasis physiologically and under pathophysiological states. Methods: A review of literature involving platelet disfunction. Results: Various presentations of platelet diseases and dysfunction challenge clinicians and require a firm understanding of normal platelet function, drugs that mediate or modulate platelet effectiveness, and nonpharmacologic etiologies of platelet diseases and dysfunction with corresponding best practice treatment approaches. Conclusion: This review summarizes normal and abnormal states associated with platelets and treatment strategies.

Original language	English (US)
Pages (from-to)	3707-3722
Number of pages	16
Journal	Advances in Therapy
Volume	37
Issue number	9
DOIs	https://doi.org/10.1007/s12325-020-01453-4
State	Published - Sep 1 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020, Springer Healthcare Ltd., part of Springer Nature.

Keywords

Hemostasis
Platelet disfunction
Systemic lupus erythematosus
Thrombotic thrombocytopenic purpura

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10.1007/s12325-020-01453-4

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title = "Platelet Dysfunction Diseases and Conditions: Clinical Implications and Considerations",

abstract = "Introduction: Platelet diseases and dysfunction are taught early in medical school to all future physicians. Understanding of the coagulation cascade and hemostatic mechanisms has allowed for targeted pharmacological therapies that have been significantly impactful in clinical practice. Platelets are an early participant in hemostasis physiologically and under pathophysiological states. Methods: A review of literature involving platelet disfunction. Results: Various presentations of platelet diseases and dysfunction challenge clinicians and require a firm understanding of normal platelet function, drugs that mediate or modulate platelet effectiveness, and nonpharmacologic etiologies of platelet diseases and dysfunction with corresponding best practice treatment approaches. Conclusion: This review summarizes normal and abnormal states associated with platelets and treatment strategies.",

keywords = "Hemostasis, Platelet disfunction, Systemic lupus erythematosus, Thrombotic thrombocytopenic purpura",

author = "Kaye, {Alan D.} and Jeha, {George M.} and Vanessa Moll and Ward, {Ceressa T.} and Watson, {Matthew R.} and Wynn, {John Thomas} and Hockstein, {Maxwell A.} and Hall, {Kevin M.} and Omar Viswanath and Ivan Urits and Amit Prabhakar and Cornett, {Elyse M.}",

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month = sep,

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doi = "10.1007/s12325-020-01453-4",

language = "English (US)",

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TY - JOUR

T1 - Platelet Dysfunction Diseases and Conditions

T2 - Clinical Implications and Considerations

AU - Kaye, Alan D.

AU - Jeha, George M.

AU - Moll, Vanessa

AU - Ward, Ceressa T.

AU - Watson, Matthew R.

AU - Wynn, John Thomas

AU - Hockstein, Maxwell A.

AU - Hall, Kevin M.

AU - Viswanath, Omar

AU - Urits, Ivan

AU - Prabhakar, Amit

AU - Cornett, Elyse M.

PY - 2020/9/1

Y1 - 2020/9/1

N2 - Introduction: Platelet diseases and dysfunction are taught early in medical school to all future physicians. Understanding of the coagulation cascade and hemostatic mechanisms has allowed for targeted pharmacological therapies that have been significantly impactful in clinical practice. Platelets are an early participant in hemostasis physiologically and under pathophysiological states. Methods: A review of literature involving platelet disfunction. Results: Various presentations of platelet diseases and dysfunction challenge clinicians and require a firm understanding of normal platelet function, drugs that mediate or modulate platelet effectiveness, and nonpharmacologic etiologies of platelet diseases and dysfunction with corresponding best practice treatment approaches. Conclusion: This review summarizes normal and abnormal states associated with platelets and treatment strategies.

AB - Introduction: Platelet diseases and dysfunction are taught early in medical school to all future physicians. Understanding of the coagulation cascade and hemostatic mechanisms has allowed for targeted pharmacological therapies that have been significantly impactful in clinical practice. Platelets are an early participant in hemostasis physiologically and under pathophysiological states. Methods: A review of literature involving platelet disfunction. Results: Various presentations of platelet diseases and dysfunction challenge clinicians and require a firm understanding of normal platelet function, drugs that mediate or modulate platelet effectiveness, and nonpharmacologic etiologies of platelet diseases and dysfunction with corresponding best practice treatment approaches. Conclusion: This review summarizes normal and abnormal states associated with platelets and treatment strategies.

KW - Hemostasis

KW - Platelet disfunction

KW - Systemic lupus erythematosus

KW - Thrombotic thrombocytopenic purpura

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SN - 0741-238X

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JO - Advances in Therapy

JF - Advances in Therapy

IS - 9

ER -

Platelet Dysfunction Diseases and Conditions: Clinical Implications and Considerations

Abstract

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Keywords

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