Platelet adhesion to novel phospholipid materials: Modified phosphatidylcholine covalently immobilized to silica, polypropylene, and PTFE materials

A. S. Köhler, P. J. Parks, D. L. Mooradian, G. H.R. Rao, L. T. Furcht

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

Based on the premise of achieving blood compatibility through mimicking the chemical constituents of the biologically inert surface of the unactivated platelet membrane, a process was developed that entails the covalent grafting of modified phosphatidylcholine molecules to materials including silica, polypropylene, and polytetrafluoroethylene (PTFE) polymer films. These materials were characterized using x-ray photoelectron spectroscopy (XPS) and contact-angle measurements. The phosphatidylcholine- containing materials (PC materials) were used as substrates in the platelet- adhesion assays and were subjected to enzymatic degradation evaluation. Phosphatidylcholine-grafted silica materials do not support platelet adhesion. In addition the number of adherent platelets correlate with the amount of grafted phospholipid present, as indicated by the phosphorus/carbon ratio obtained by XPS analysis. Platelet adhesion to phosphatidylcholine- grafted polypropylene and PTFE was inhibited 80% and 90%, respectively, when compared with platelet adhesion to unmodified polypropylene and PTFE.

Original languageEnglish (US)
Pages (from-to)237-242
Number of pages6
JournalJournal of Biomedical Materials Research
Volume32
Issue number2
DOIs
StatePublished - Oct 1996

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