Based on the premise of achieving blood compatibility through mimicking the chemical constituents of the biologically inert surface of the unactivated platelet membrane, a process was developed that entails the covalent grafting of modified phosphatidylcholine molecules to materials including silica, polypropylene, and polytetrafluoroethylene (PTFE) polymer films. These materials were characterized using x-ray photoelectron spectroscopy (XPS) and contact-angle measurements. The phosphatidylcholine- containing materials (PC materials) were used as substrates in the platelet- adhesion assays and were subjected to enzymatic degradation evaluation. Phosphatidylcholine-grafted silica materials do not support platelet adhesion. In addition the number of adherent platelets correlate with the amount of grafted phospholipid present, as indicated by the phosphorus/carbon ratio obtained by XPS analysis. Platelet adhesion to phosphatidylcholine- grafted polypropylene and PTFE was inhibited 80% and 90%, respectively, when compared with platelet adhesion to unmodified polypropylene and PTFE.
|Original language||English (US)|
|Number of pages||6|
|Journal||Journal of Biomedical Materials Research|
|State||Published - Oct 1996|