A plasmonic nanohole sensor for virus-like particle capture and virucidal drug evaluation is reported. Using a materials-selective surface functionalization scheme, passive immobilization of virus-like particles only within the nanoholes is achieved. The findings demonstrate that a low surface coverage of particles only inside the functionalized nanoholes significantly improves nanoplasmonic sensing performance over conventional nanohole arrays.
Bibliographical noteFunding Information:
The authors thank Dr. Olof Andersson for assistance with data analysis and Dr. Sven Hobbie for supplying virus reagents. This work was supported by the National Research Foundation grant NRF‐NRFF2011–01 (N.‐J.C.) and the National Medical Research Council grant NMRC/CBRG/0005/2012 (N.‐J.C.). S.H.O. and N.J.W. acknowledge support from the U.S. National Science Foundation (NSF CAREER Award) and the MnDRIVE Research Initiative.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Copyright 2017 Elsevier B.V., All rights reserved.
- sensors, biosensors, nanohole arrays