Plasmonic Nanohole Sensor for Capturing Single Virus-Like Particles toward Virucidal Drug Evaluation

Joshua A. Jackman, Eric Linardy, Daehan Yoo, Jeongeun Seo, Wei Beng Ng, Daniel J. Klemme, Nathan J. Wittenberg, Sang Hyun Oh, Nam Joon Cho

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

A plasmonic nanohole sensor for virus-like particle capture and virucidal drug evaluation is reported. Using a materials-selective surface functionalization scheme, passive immobilization of virus-like particles only within the nanoholes is achieved. The findings demonstrate that a low surface coverage of particles only inside the functionalized nanoholes significantly improves nanoplasmonic sensing performance over conventional nanohole arrays.

Original languageEnglish (US)
Pages (from-to)1159-1166
Number of pages8
JournalSmall
Volume12
Issue number9
DOIs
StatePublished - Mar 2 2016

Bibliographical note

Funding Information:
The authors thank Dr. Olof Andersson for assistance with data analysis and Dr. Sven Hobbie for supplying virus reagents. This work was supported by the National Research Foundation grant NRF‐NRFF2011–01 (N.‐J.C.) and the National Medical Research Council grant NMRC/CBRG/0005/2012 (N.‐J.C.). S.H.O. and N.J.W. acknowledge support from the U.S. National Science Foundation (NSF CAREER Award) and the MnDRIVE Research Initiative.

Publisher Copyright:
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

Keywords

  • biosensing
  • peptides
  • plasmonics
  • sensors, biosensors, nanohole arrays
  • viruses

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