Plasmonic Nanohole Sensor for Capturing Single Virus-Like Particles toward Virucidal Drug Evaluation

Joshua A. Jackman, Eric Linardy, Daehan Yoo, Jeongeun Seo, Wei Beng Ng, Daniel J. Klemme, Nathan J. Wittenberg, Sang Hyun Oh, Nam Joon Cho

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

A plasmonic nanohole sensor for virus-like particle capture and virucidal drug evaluation is reported. Using a materials-selective surface functionalization scheme, passive immobilization of virus-like particles only within the nanoholes is achieved. The findings demonstrate that a low surface coverage of particles only inside the functionalized nanoholes significantly improves nanoplasmonic sensing performance over conventional nanohole arrays.

Original languageEnglish (US)
Pages (from-to)1159-1166
Number of pages8
JournalSmall
Volume12
Issue number9
DOIs
StatePublished - Mar 2 2016

Keywords

  • biosensing
  • peptides
  • plasmonics
  • sensors, biosensors, nanohole arrays
  • viruses

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  • Cite this

    Jackman, J. A., Linardy, E., Yoo, D., Seo, J., Ng, W. B., Klemme, D. J., Wittenberg, N. J., Oh, S. H., & Cho, N. J. (2016). Plasmonic Nanohole Sensor for Capturing Single Virus-Like Particles toward Virucidal Drug Evaluation. Small, 12(9), 1159-1166. https://doi.org/10.1002/smll.201501914