Plasmonic nanohole arrays for real-time multiplex biosensing

Antoine Lesuffleur, Hyungsoon Im, Nathan C. Lindquist, Kwan Seop Lim, Sang Hyun Oh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

12 Scopus citations


Large-scale studies of biomolecular interactions required for proteome-level investigations can benefit from a new class of emerging surface plasmon resonance (SPR) sensors: nanohole arrays and surface plasmon (SP) enhanced optical transmission. In this paper we present a real-time, label-free multiplex SPR imaging sensor in a microarray format. The system presented is built around a low-cost microscope with laser illumination, integrated with microfluidics. The specific binding kinetics of biotin and streptavidin are measured from several sensing elements simultaneously, demonstrating the feasibility of using nanohole arrays as a high-throughput SPR microarray sensor.

Original languageEnglish (US)
Title of host publicationBiosensing
StatePublished - 2008
EventBiosensing - San Diego, CA, United States
Duration: Aug 12 2008Aug 14 2008

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
ISSN (Print)0277-786X


Country/TerritoryUnited States
CitySan Diego, CA


  • Periodic nanohole arrays
  • Plasmonics
  • Real-time label-free biosensing
  • Surface plasmon resonance imaging


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