Plasmonic nanobubbles enhance efficacy and selectivity of chemotherapy against drug-resistant cancer cells

Ekaterina Y. Lukianova-Hleb, Xiaoyang Ren, Joseph A. Zasadzinski, Xiangwei Wu, Dmitri O. Lapotko

Research output: Contribution to journalArticlepeer-review

78 Scopus citations

Abstract

Plasmonic nanobubbles, new multifunctional cellular nano-agents, are selectively generated in target cancer cells with a short near-infrared laser pulse. The enhanced cellular specificity and tunable transient nature of plasmonic nanobubbles provide fast, efficient and selective dual therapeutic effects: intracellular delivery of a drug and direct mechanical destruction of cells while sparing normal cells, and reduce drug dose and overcome drug-resistance of cancer cells.

Original languageEnglish (US)
Pages (from-to)3831-3837
Number of pages7
JournalAdvanced Materials
Volume24
Issue number28
DOIs
StatePublished - Jul 24 2012

Keywords

  • Doxil
  • cancer
  • drug resistance
  • gold nanoparticles
  • laser
  • plasmonic nanobubbles

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