Plasminogen activator activities in the ventral and dorsolateral prostatic lobes of aging fischer 344 rats

Michael J. Wilson, Janet V. Ditmanson, Akhouri A Sinha, Richard D. Estensen

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17 Scopus citations

Abstract

Plasminogen activator (PA) activities were measured in extracts of ventral and dorsolateral prostate lobes in Fischer 344 (F344) rats of different ages. Ventral prostates of 30‐month‐old animals demonstrated widespread epithelial atrophy, some foci of inflammation, in‐traglandular atypical hyperplasia and/or adenocarcinoma, and a marked increase in PA activities compared with younger animals. Both low‐ and high‐molecular‐weight forms of activator were found in zymograms and both forms of activator showed an increase at 30 months. However, the PA activity of the aged rats showed a greater resistance to amiloride inhibition, suggesting a greater relative increase in the tissue‐type activator activity than that of urokinase. These changes were not observed in the dorsolateral prostate. The lobe‐specific changes in activator activity appear related to dysplasia/neoplasia and not aging.

Original languageEnglish (US)
Pages (from-to)147-161
Number of pages15
JournalThe Prostate
Volume16
Issue number2
DOIs
StatePublished - 1990

Keywords

  • adenocarcinoma
  • amiloride
  • tissue‐type plasminogen activator
  • urokinase

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