1. Plasma uric acid levels were determined in ethanol-fed poults following administration of allopurinol. 2. In young poults, allopurinol at a dose of 50 mg/kg significantly depressed plasma uric acid levels 6 hr post-dosing. At 11 hr post-dosing, plasma uric acid levels were significantly elevated in the allopurinol-treated poults when compared with control poults. 3. During a period of ethanol abstinence, allopurinol at a dose of 40 mg/kg significantly depressed plasma uric acid levels up to 8 hr post-dosing. At a dose of 30 mg/kg, plasma uric acid levels were similar to control values at 4 and 6 hr post-dosing. 4. Data suggest that plasma uric acid levels can be depressed in ethanol poults when allopurinol is administered every 8 hr at a dose of 40-50 mg/kg of body weight.
|Original language||English (US)|
|Number of pages||3|
|Journal||Comparative Biochemistry and Physiology. Part C, Comparative|
|State||Published - 1987|
Bibliographical noteFunding Information:
Ackno,~lerlgemen~.~-aTuhteh ors acknowledge the assistance of Carl W. Edborg, III and Mark Pessin in the care of the poults. This work was supported by a grant from Alcohol and Other Drug Abuse Programming, University of Minnesota.
Copyright 2014 Elsevier B.V., All rights reserved.