Abstract
1. Plasma uric acid levels were determined in ethanol-fed poults following administration of allopurinol. 2. In young poults, allopurinol at a dose of 50 mg/kg significantly depressed plasma uric acid levels 6 hr post-dosing. At 11 hr post-dosing, plasma uric acid levels were significantly elevated in the allopurinol-treated poults when compared with control poults. 3. During a period of ethanol abstinence, allopurinol at a dose of 40 mg/kg significantly depressed plasma uric acid levels up to 8 hr post-dosing. At a dose of 30 mg/kg, plasma uric acid levels were similar to control values at 4 and 6 hr post-dosing. 4. Data suggest that plasma uric acid levels can be depressed in ethanol poults when allopurinol is administered every 8 hr at a dose of 40-50 mg/kg of body weight.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 63-65 |
| Number of pages | 3 |
| Journal | Comparative Biochemistry and Physiology. Part C, Comparative |
| Volume | 86 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1987 |
Bibliographical note
Funding Information:Ackno,~lerlgemen~.~-aTuhteh ors acknowledge the assistance of Carl W. Edborg, III and Mark Pessin in the care of the poults. This work was supported by a grant from Alcohol and Other Drug Abuse Programming, University of Minnesota.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.