Plasma target enzyme desensitization following chronic morphine treatment in rats

B. Banerjee, S. C. Basak, J. J. Ghosh

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Rat plasma cholinesterase and arylamidase were measured during morphine-induced desensitization. Evidence is presented in support of the view that prolonged morphine treatment brings about desensitization to the initial action of the drug. This desensitized state persists even after eight days of withdrawal. It is suggested that these enzymes may constitute convenient target systems for studying opiate tolerance.

Original languageEnglish (US)
Pages (from-to)629-630
Number of pages2
JournalIRCS Medical Science
Volume9
Issue number7
StatePublished - Jan 1 1981

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