Rat plasma cholinesterase and arylamidase were measured during morphine-induced desensitization. Evidence is presented in support of the view that prolonged morphine treatment brings about desensitization to the initial action of the drug. This desensitized state persists even after eight days of withdrawal. It is suggested that these enzymes may constitute convenient target systems for studying opiate tolerance.
|Original language||English (US)|
|Number of pages||2|
|Journal||IRCS Medical Science|
|State||Published - Jan 1 1981|