Plasma target enzyme desensitization following chronic morphine treatment in rats

B. Banerjee; S. C. Basak; J. J. Ghosh

Plasma target enzyme desensitization following chronic morphine treatment in rats

B. Banerjee, S. C. Basak, J. J. Ghosh

Natural Resources Research Institute

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2 Scopus citations

Abstract

Rat plasma cholinesterase and arylamidase were measured during morphine-induced desensitization. Evidence is presented in support of the view that prolonged morphine treatment brings about desensitization to the initial action of the drug. This desensitized state persists even after eight days of withdrawal. It is suggested that these enzymes may constitute convenient target systems for studying opiate tolerance.

Original language	English (US)
Pages (from-to)	629-630
Number of pages	2
Journal	IRCS Medical Science
Volume	9
Issue number	7
State	Published - Jan 1 1981

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title = "Plasma target enzyme desensitization following chronic morphine treatment in rats",

abstract = "Rat plasma cholinesterase and arylamidase were measured during morphine-induced desensitization. Evidence is presented in support of the view that prolonged morphine treatment brings about desensitization to the initial action of the drug. This desensitized state persists even after eight days of withdrawal. It is suggested that these enzymes may constitute convenient target systems for studying opiate tolerance.",

author = "B. Banerjee and Basak, {S. C.} and Ghosh, {J. J.}",

year = "1981",

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T1 - Plasma target enzyme desensitization following chronic morphine treatment in rats

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AU - Basak, S. C.

AU - Ghosh, J. J.

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N2 - Rat plasma cholinesterase and arylamidase were measured during morphine-induced desensitization. Evidence is presented in support of the view that prolonged morphine treatment brings about desensitization to the initial action of the drug. This desensitized state persists even after eight days of withdrawal. It is suggested that these enzymes may constitute convenient target systems for studying opiate tolerance.

AB - Rat plasma cholinesterase and arylamidase were measured during morphine-induced desensitization. Evidence is presented in support of the view that prolonged morphine treatment brings about desensitization to the initial action of the drug. This desensitized state persists even after eight days of withdrawal. It is suggested that these enzymes may constitute convenient target systems for studying opiate tolerance.

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JO - IRCS Medical Science

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Plasma target enzyme desensitization following chronic morphine treatment in rats

Abstract

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