Abstract
We investigated the associations between steroid hormones and resting and exercise blood pressure in the sedentary state and in response to an exercise program controlling for sex, body mass, ethnicity, age, oral contraceptives, hormone therapy, smoking and alcohol intake in subjects from the HERITAGE Family Study. In the sedentary state, 267 men (28% Blacks) and 301 women (37% Blacks) were available, and 241 men and 254 women completed the exercise program. Fourteen steroid hormones and sex hormone-binding globulin concentrations were assayed in a fasted state. Statistical significance was set at a Bonferroni adjusted p<0.0001. After controlling for the various covariates, only testosterone came close to a significant correlation with exercise systolic blood pressure at 50 W (r=-0.21, P=0.0006) in men. No other correlations with resting and exercise blood pressure traits were found at baseline. There were significant changes in blood pressure in response to the exercise program, but none of the correlations with baseline plasma steroids reached statistical significance. Plasma steroids do not correlate with resting and exercise blood pressure in sedentary adults and do not associate with blood pressure changes in response to a 20-week endurance exercise program.
Original language | English (US) |
---|---|
Pages (from-to) | 967-971 |
Number of pages | 5 |
Journal | International Journal of Sports Medicine |
Volume | 39 |
Issue number | 13 |
DOIs | |
State | Published - Jan 1 2018 |
Bibliographical note
Funding Information:The HERITAGE Family Study has been supported over the years by multiple grants from the National Institute for Heart, Lung and Blood Diseases of the National Institutes of Health (HL45670, C. Bouchard and T. Rankinen; HL47323, A.S. Leon; HL47327, J.S. Skinner). CB is partially funded by the John W. Barton Sr. Chair in Genetics and Nutrition. CB is also supported in part by a COBRE center grant from the National Institute of Health (NIH8 1P30GM118430-02). Zihong He is funded by the China Scholarship Council (File No. 201603620001) and China Institute of Sport Science (2015-01, 2016-01). We would like to express our gratitude to Dr. Alain ?elanger (retired) and his sta ? from the Molecular Endocrinology Laboratory of the Laval University Medical Center in Quebec City, Canada, for the assays of the steroids and their dedication to the HERITAGE Family Study. Disclosures AT receives research funding from Johnson & Johnson Medical Companies for studies unrelated to the present paper.
Publisher Copyright:
© Georg Thieme Verlag KG Stuttgart New York.
Keywords
- endurance exercise
- hypertension
- sedentary
- submaximal intensity
PubMed: MeSH publication types
- Journal Article