Plasma phospholipid N-3/N-6 polyunsaturated fatty acids and desaturase activities in relation to moderate-to-vigorous physical activity through pregnancy: A longitudinal study within the NICHD fetal growth studies

Liwei Chen, Yeyi Zhu, Zhe Fei, Stefanie N. Hinkle, Tong Xia, Xinyue Liu, Mohammad L. Rahman, Mengying Li, Jing Wu, Natalie L. Weir, Michael Y. Tsai, Cuilin Zhang

Research output: Contribution to journalArticlepeer-review

Abstract

Maternal plasma phospholipid polyunsaturated fatty acids (PUFAs) play critical roles in maternal health and fetal development. Beyond dietary factors, maternal moderate-to-vigorous physical activity (MVPA) has been linked to multiple health benefits for both the mother and offspring, but studies investigating the influence of maternal MVPA on maternal PUFA profile are scarce. The objective of present study was to examine the time-specific and prospective associations of MVPA with plasma PUFA profile among pregnant women. This study included 321 participants from the National Institute of Child Health and Human Development (NICHD) Fetal Growth Studies–Singletons cohort. Maternal plasma phospholipid PUFAs and MPVA were measured at four visits during pregnancy (10–14, 15–26, 23–31, and 33–39 gestational weeks (GW)). Associations of maternal MVPA with individual plasma PUFAs and desaturase activity were examined using generalized linear models. Maternal MVPA was associated inversely with plasma phospholipid linoleic acid, gamma-linolenic acid, and ∆6-desaturase in late pregnancy (23–31 or 33–39 GW), independent of maternal age, race, education, parity, pre-pregnancy body mass index, and dietary factors. Findings from this longitudinal study indicate that maternal habitual MVPA may play a role on PUFAs metabolism, particular by alerting plasma n-6 subclass and desaturase activity in late pregnancy. These associations are novel and merit confirmation in future studies.

Original languageEnglish (US)
Article number3544
Pages (from-to)1-15
Number of pages15
JournalNutrients
Volume12
Issue number11
DOIs
StatePublished - Nov 2020

Bibliographical note

Funding Information:
Funding: This research was supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) intramural funding and included American Recovery and Reinvestment Act funding via contract numbers HHSN275200800013C, HHSN275200800002I, HHSN27500006, HHSN275200800003IC, HHSN275200800014C, HHSN275200800012C, HHSN275200800028C, HHSN275201000009C, and HHSN275201000001Z; NICHD grant R01HD082311 (LC); and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) grant K01DK120807 (Y.Z.).

Keywords

  • Physical activity
  • Polyunsaturated fatty acids (PUFAs)
  • Pregnant women

PubMed: MeSH publication types

  • Journal Article

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