Plasma Phospholipid Monounsaturated Fatty Acids and Gestational Diabetes Mellitus: A Longitudinal Study in the NICHD Fetal Growth Studies–Singletons Cohort

Kit Ying Tsoi; Yeyi Zhu; Jing Wu; Qi Sun; Stefanie N. Hinkle; Ling Jun Li; Zhen Chen; Natalie A Weir; Michael Y. Tsai; Ronald C.W. Ma; Cuilin Zhang

doi:10.2337/db22-0241

Plasma Phospholipid Monounsaturated Fatty Acids and Gestational Diabetes Mellitus: A Longitudinal Study in the NICHD Fetal Growth Studies–Singletons Cohort

Kit Ying Tsoi, Yeyi Zhu, Jing Wu, Qi Sun, Stefanie N. Hinkle, Ling Jun Li, Zhen Chen, Natalie A Weir, Michael Y. Tsai, Ronald C.W. Ma, Cuilin Zhang

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Fatty acids (FAs) have been implicated in the development of gestational diabetes mellitus (GDM), but the role of monounsaturated FAs (MUFAs) remains understudied. We investigated the associations of plasma phospholipid MUFAs in early to mid-pregnancy with cardiometabolic biomarkers and GDM risk. From the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Fetal Growth Studies-Singletons cohort (2009–2013), we identified 107 women with GDM according to Carpenter and Coustan criteria and 214 control participants without GDM matched (2:1) on age, race/ ethnicity, and gestational week (GW) of blood collection. MUFAs were measured at 10–14, 15–26, 23–31, and 33–39 GWs by gas chromatography mass spectrometry. We found that the concentration of total 18:1 MUFAs was significantly lower among women with GDM than those without GDM at 15–26 GWs. Each SD increment in the level of total 18:1 MUFAs was associated with a 40% lower risk of GDM at 15–26 GWs. Moreover, each SD increment in vaccenic acid (18:1n-7) levels at 10–14 and 15–26 GWs were associated with a 36% and 45% lower risk of GDM, respectively. Our extensive assessments of MUFAs advance our understanding of the unique associations of FA composition with GDM risk, suggesting the potentially beneficial role of MUFAs in GDM pathophysiology.

Original language	English (US)
Pages (from-to)	2707-2715
Number of pages	9
Journal	Diabetes
Volume	71
Issue number	12
DOIs	https://doi.org/10.2337/db22-0241
State	Published - Dec 2022

Bibliographical note

Funding Information:
K.Y.T. is supported by The Chinese University of Hong Kong Faculty Postdoctoral Fellowship Scheme. Y.Z. was supported by the National Institute of Diabetes and Digestive and Kidney Diseases (grant K01DK120807). This research was supported by Eunice Kennedy Shriver National Institute of Child Health and Human Development intramural funding and American Recovery and Reinvestment Act funding (grants HHSN275200800013C, HHSN275200800002I, HHSN27500006, HHSN275200800003IC, HHSN275200800014C, HHSN275200800012C, HHSN-275200800028C, HHSN275201000009C, and HHSN275201000001Z).

Publisher Copyright:
© 2022 by the American Diabetes Association.

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title = "Plasma Phospholipid Monounsaturated Fatty Acids and Gestational Diabetes Mellitus: A Longitudinal Study in the NICHD Fetal Growth Studies–Singletons Cohort",

abstract = "Fatty acids (FAs) have been implicated in the development of gestational diabetes mellitus (GDM), but the role of monounsaturated FAs (MUFAs) remains understudied. We investigated the associations of plasma phospholipid MUFAs in early to mid-pregnancy with cardiometabolic biomarkers and GDM risk. From the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Fetal Growth Studies-Singletons cohort (2009–2013), we identified 107 women with GDM according to Carpenter and Coustan criteria and 214 control participants without GDM matched (2:1) on age, race/ ethnicity, and gestational week (GW) of blood collection. MUFAs were measured at 10–14, 15–26, 23–31, and 33–39 GWs by gas chromatography mass spectrometry. We found that the concentration of total 18:1 MUFAs was significantly lower among women with GDM than those without GDM at 15–26 GWs. Each SD increment in the level of total 18:1 MUFAs was associated with a 40% lower risk of GDM at 15–26 GWs. Moreover, each SD increment in vaccenic acid (18:1n-7) levels at 10–14 and 15–26 GWs were associated with a 36% and 45% lower risk of GDM, respectively. Our extensive assessments of MUFAs advance our understanding of the unique associations of FA composition with GDM risk, suggesting the potentially beneficial role of MUFAs in GDM pathophysiology.",

author = "Tsoi, {Kit Ying} and Yeyi Zhu and Jing Wu and Qi Sun and Hinkle, {Stefanie N.} and Li, {Ling Jun} and Zhen Chen and Weir, {Natalie A} and Tsai, {Michael Y.} and Ma, {Ronald C.W.} and Cuilin Zhang",

note = "Funding Information: K.Y.T. is supported by The Chinese University of Hong Kong Faculty Postdoctoral Fellowship Scheme. Y.Z. was supported by the National Institute of Diabetes and Digestive and Kidney Diseases (grant K01DK120807). This research was supported by Eunice Kennedy Shriver National Institute of Child Health and Human Development intramural funding and American Recovery and Reinvestment Act funding (grants HHSN275200800013C, HHSN275200800002I, HHSN27500006, HHSN275200800003IC, HHSN275200800014C, HHSN275200800012C, HHSN-275200800028C, HHSN275201000009C, and HHSN275201000001Z). Publisher Copyright: {\textcopyright} 2022 by the American Diabetes Association.",

year = "2022",

month = dec,

doi = "10.2337/db22-0241",

language = "English (US)",

volume = "71",

pages = "2707--2715",

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T1 - Plasma Phospholipid Monounsaturated Fatty Acids and Gestational Diabetes Mellitus

T2 - A Longitudinal Study in the NICHD Fetal Growth Studies–Singletons Cohort

AU - Tsoi, Kit Ying

AU - Zhu, Yeyi

AU - Wu, Jing

AU - Sun, Qi

AU - Hinkle, Stefanie N.

AU - Li, Ling Jun

AU - Chen, Zhen

AU - Weir, Natalie A

AU - Tsai, Michael Y.

AU - Ma, Ronald C.W.

AU - Zhang, Cuilin

N1 - Funding Information: K.Y.T. is supported by The Chinese University of Hong Kong Faculty Postdoctoral Fellowship Scheme. Y.Z. was supported by the National Institute of Diabetes and Digestive and Kidney Diseases (grant K01DK120807). This research was supported by Eunice Kennedy Shriver National Institute of Child Health and Human Development intramural funding and American Recovery and Reinvestment Act funding (grants HHSN275200800013C, HHSN275200800002I, HHSN27500006, HHSN275200800003IC, HHSN275200800014C, HHSN275200800012C, HHSN-275200800028C, HHSN275201000009C, and HHSN275201000001Z). Publisher Copyright: © 2022 by the American Diabetes Association.

PY - 2022/12

Y1 - 2022/12

N2 - Fatty acids (FAs) have been implicated in the development of gestational diabetes mellitus (GDM), but the role of monounsaturated FAs (MUFAs) remains understudied. We investigated the associations of plasma phospholipid MUFAs in early to mid-pregnancy with cardiometabolic biomarkers and GDM risk. From the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Fetal Growth Studies-Singletons cohort (2009–2013), we identified 107 women with GDM according to Carpenter and Coustan criteria and 214 control participants without GDM matched (2:1) on age, race/ ethnicity, and gestational week (GW) of blood collection. MUFAs were measured at 10–14, 15–26, 23–31, and 33–39 GWs by gas chromatography mass spectrometry. We found that the concentration of total 18:1 MUFAs was significantly lower among women with GDM than those without GDM at 15–26 GWs. Each SD increment in the level of total 18:1 MUFAs was associated with a 40% lower risk of GDM at 15–26 GWs. Moreover, each SD increment in vaccenic acid (18:1n-7) levels at 10–14 and 15–26 GWs were associated with a 36% and 45% lower risk of GDM, respectively. Our extensive assessments of MUFAs advance our understanding of the unique associations of FA composition with GDM risk, suggesting the potentially beneficial role of MUFAs in GDM pathophysiology.

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Plasma Phospholipid Monounsaturated Fatty Acids and Gestational Diabetes Mellitus: A Longitudinal Study in the NICHD Fetal Growth Studies–Singletons Cohort

Abstract

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