Abstract
Sufficient evidence exists that plasma fibrinogen is a risk factor for cardiovascular disease to prompt a search for fibrinogen determinants. The authors measured fibnnogen in 4, 193 participants in the Coronary Artery Risk Development in Young Adults (CARDIA) Study with three objectives: to describe fibrinogen levels in young adults, to determine if correlates of fibrinogen in older adults apply to younger adults, and to examine several additional hypothesized correlates. Fibrinogen (overall mean ± standard deviation = 263 ± 57 mg/dl) was greater in women than in men and in blacks than in whites; it was associated positively with cigarette smoking, body mass index, low density lipoprotein cholesterol, triglycerides, and blood pressure, and negatively with physical activity, high density lipoprotein cholesterol, and ethanol intake. Socioeconomic stress indicators and negative personality traits hypothesized as being associated with fibrinogen, possibly through adrenergic mechanisms, proved weak correlates. Parental history of diabetes was correlated positively with fibrinogen, in part because those with a positive parental history had greater body mass. Diabetes mellitus, lipoprotein(a), left ventricular mass, and oral contraceptive use were also positively correlated with fibrinogen concentration. Thus, even in young adults, fibrinogen is associated positively with most risk factors for atherosclerotic cardiovascular disease. This has implications for the role of fibrinogen as a risk factor and, potentially, for cardiovascular disease prevention.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1023-1036 |
| Number of pages | 14 |
| Journal | American journal of epidemiology |
| Volume | 138 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 15 1993 |
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Keywords
- Blood coagulation factors
- Coronary disease
- Fibrinogen
Cite this
Plasma fibrinogen : Levels and correlates in young adults. / Folsom, Aaron R.; Qamhieh, Hekmat T.; Flack, John M.; Hilner, Joan E.; Liu, Kiang; Howard, Barbara V.; Tracy, Russell P.
In: American journal of epidemiology, Vol. 138, No. 12, 15.12.1993, p. 1023-1036.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Plasma fibrinogen
T2 - Levels and correlates in young adults
AU - Folsom, Aaron R.
AU - Qamhieh, Hekmat T.
AU - Flack, John M.
AU - Hilner, Joan E.
AU - Liu, Kiang
AU - Howard, Barbara V.
AU - Tracy, Russell P.
PY - 1993/12/15
Y1 - 1993/12/15
N2 - Sufficient evidence exists that plasma fibrinogen is a risk factor for cardiovascular disease to prompt a search for fibrinogen determinants. The authors measured fibnnogen in 4, 193 participants in the Coronary Artery Risk Development in Young Adults (CARDIA) Study with three objectives: to describe fibrinogen levels in young adults, to determine if correlates of fibrinogen in older adults apply to younger adults, and to examine several additional hypothesized correlates. Fibrinogen (overall mean ± standard deviation = 263 ± 57 mg/dl) was greater in women than in men and in blacks than in whites; it was associated positively with cigarette smoking, body mass index, low density lipoprotein cholesterol, triglycerides, and blood pressure, and negatively with physical activity, high density lipoprotein cholesterol, and ethanol intake. Socioeconomic stress indicators and negative personality traits hypothesized as being associated with fibrinogen, possibly through adrenergic mechanisms, proved weak correlates. Parental history of diabetes was correlated positively with fibrinogen, in part because those with a positive parental history had greater body mass. Diabetes mellitus, lipoprotein(a), left ventricular mass, and oral contraceptive use were also positively correlated with fibrinogen concentration. Thus, even in young adults, fibrinogen is associated positively with most risk factors for atherosclerotic cardiovascular disease. This has implications for the role of fibrinogen as a risk factor and, potentially, for cardiovascular disease prevention.
AB - Sufficient evidence exists that plasma fibrinogen is a risk factor for cardiovascular disease to prompt a search for fibrinogen determinants. The authors measured fibnnogen in 4, 193 participants in the Coronary Artery Risk Development in Young Adults (CARDIA) Study with three objectives: to describe fibrinogen levels in young adults, to determine if correlates of fibrinogen in older adults apply to younger adults, and to examine several additional hypothesized correlates. Fibrinogen (overall mean ± standard deviation = 263 ± 57 mg/dl) was greater in women than in men and in blacks than in whites; it was associated positively with cigarette smoking, body mass index, low density lipoprotein cholesterol, triglycerides, and blood pressure, and negatively with physical activity, high density lipoprotein cholesterol, and ethanol intake. Socioeconomic stress indicators and negative personality traits hypothesized as being associated with fibrinogen, possibly through adrenergic mechanisms, proved weak correlates. Parental history of diabetes was correlated positively with fibrinogen, in part because those with a positive parental history had greater body mass. Diabetes mellitus, lipoprotein(a), left ventricular mass, and oral contraceptive use were also positively correlated with fibrinogen concentration. Thus, even in young adults, fibrinogen is associated positively with most risk factors for atherosclerotic cardiovascular disease. This has implications for the role of fibrinogen as a risk factor and, potentially, for cardiovascular disease prevention.
KW - Blood coagulation factors
KW - Coronary disease
KW - Fibrinogen
UR - http://www.scopus.com/inward/record.url?scp=0027772170&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027772170&partnerID=8YFLogxK
U2 - 10.1093/oxfordjournals.aje.a116821
DO - 10.1093/oxfordjournals.aje.a116821
M3 - Article
VL - 138
SP - 1023
EP - 1036
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
SN - 0002-9262
IS - 12
ER -