Plasma fibrinogen

Levels and correlates in young adults

Aaron R. Folsom, Hekmat T. Qamhieh, John M. Flack, Joan E. Hilner, Kiang Liu, Barbara V. Howard, Russell P. Tracy

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

Sufficient evidence exists that plasma fibrinogen is a risk factor for cardiovascular disease to prompt a search for fibrinogen determinants. The authors measured fibnnogen in 4, 193 participants in the Coronary Artery Risk Development in Young Adults (CARDIA) Study with three objectives: to describe fibrinogen levels in young adults, to determine if correlates of fibrinogen in older adults apply to younger adults, and to examine several additional hypothesized correlates. Fibrinogen (overall mean ± standard deviation = 263 ± 57 mg/dl) was greater in women than in men and in blacks than in whites; it was associated positively with cigarette smoking, body mass index, low density lipoprotein cholesterol, triglycerides, and blood pressure, and negatively with physical activity, high density lipoprotein cholesterol, and ethanol intake. Socioeconomic stress indicators and negative personality traits hypothesized as being associated with fibrinogen, possibly through adrenergic mechanisms, proved weak correlates. Parental history of diabetes was correlated positively with fibrinogen, in part because those with a positive parental history had greater body mass. Diabetes mellitus, lipoprotein(a), left ventricular mass, and oral contraceptive use were also positively correlated with fibrinogen concentration. Thus, even in young adults, fibrinogen is associated positively with most risk factors for atherosclerotic cardiovascular disease. This has implications for the role of fibrinogen as a risk factor and, potentially, for cardiovascular disease prevention.

Original languageEnglish (US)
Pages (from-to)1023-1036
Number of pages14
JournalAmerican journal of epidemiology
Volume138
Issue number12
DOIs
StatePublished - Dec 15 1993

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Fibrinogen
Young Adult
Cardiovascular Diseases
Lipoprotein(a)
Oral Contraceptives
Adrenergic Agents
LDL Cholesterol
HDL Cholesterol
Personality
Coronary Vessels
Diabetes Mellitus
Body Mass Index
Ethanol
Smoking
Exercise
Blood Pressure

Keywords

  • Blood coagulation factors
  • Coronary disease
  • Fibrinogen

Cite this

Folsom, A. R., Qamhieh, H. T., Flack, J. M., Hilner, J. E., Liu, K., Howard, B. V., & Tracy, R. P. (1993). Plasma fibrinogen: Levels and correlates in young adults. American journal of epidemiology, 138(12), 1023-1036. https://doi.org/10.1093/oxfordjournals.aje.a116821

Plasma fibrinogen : Levels and correlates in young adults. / Folsom, Aaron R.; Qamhieh, Hekmat T.; Flack, John M.; Hilner, Joan E.; Liu, Kiang; Howard, Barbara V.; Tracy, Russell P.

In: American journal of epidemiology, Vol. 138, No. 12, 15.12.1993, p. 1023-1036.

Research output: Contribution to journalArticle

Folsom, AR, Qamhieh, HT, Flack, JM, Hilner, JE, Liu, K, Howard, BV & Tracy, RP 1993, 'Plasma fibrinogen: Levels and correlates in young adults', American journal of epidemiology, vol. 138, no. 12, pp. 1023-1036. https://doi.org/10.1093/oxfordjournals.aje.a116821
Folsom, Aaron R. ; Qamhieh, Hekmat T. ; Flack, John M. ; Hilner, Joan E. ; Liu, Kiang ; Howard, Barbara V. ; Tracy, Russell P. / Plasma fibrinogen : Levels and correlates in young adults. In: American journal of epidemiology. 1993 ; Vol. 138, No. 12. pp. 1023-1036.
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