Plasma concentrations of lipids during pregnancy and the risk of gestational diabetes mellitus: A longitudinal study

Wei Bao; Sharon Dar; Yeyi Zhu; Jing Wu; Shristi Rawal; Shanshan Li; Natalie L. Weir; Michael Y. Tsai; Cuilin Zhang

doi:10.1111/1753-0407.12563

Plasma concentrations of lipids during pregnancy and the risk of gestational diabetes mellitus: A longitudinal study

Wei Bao, Sharon Dar, Yeyi Zhu, Jing Wu, Shristi Rawal, Shanshan Li, Natalie L. Weir, Michael Y. Tsai, Cuilin Zhang

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

Background: Abnormal lipid profiles have been associated with gestational diabetes mellitus (GDM), but studies with longitudinal measures of lipids throughout pregnancy are sparse. The aim of the present study was to characterize longitudinal changes in lipid profiles throughout pregnancy and prospectively examine the associations of plasma lipid concentrations with risk of GDM. Methods: This study was a nested case-control study including 107 GDM cases and 214 matched non-GDM controls from participants in the National Institute of Child Health and Human Development (NICHD) Fetal Growth Studies – Singleton cohort. Blood samples were collected longitudinally at Gestational Weeks (GW) 10–14, 15–26 (fasting sample), 23–31, and 33–39. Plasma concentrations of triglycerides, total cholesterol, and high-density lipoprotein cholesterol (HDL-C) were measured by enzymatic assays. Low-density lipoprotein cholesterol (LDL-C) was calculated using Friedewald's formula. Results: Plasma triglycerides, total cholesterol, and LDL-C increased as pregnancy progressed. At GW 10–14, the adjusted odds ratios (aORs) of GDM comparing the highest versus lowest quartile were 3.15 (95% confidence interval [CI] 1.38–7.15; P _trend = 0.002) for triglycerides and 0.44 (95% CI 0.18–1.09; P _trend = 0.045) for HDL-C. At GW 15–26, the aORs were 6.57 (95% CI 2.25–19.17; P _trend = 0.001) for triglycerides and 0.23 (95% CI 0.08–0.63; P _trend = 0.005) for HDL-C. No significant associations were observed for total cholesterol and LDL-C concentrations with risk of GDM. Conclusions: Higher plasma triglyceride and lower HDL-C concentrations in early and mid-pregnancy were significantly associated with a greater risk of GDM. Total cholesterol and LDL-C concentrations during pregnancy were not significantly associated with GDM risk.

Original language	English (US)
Pages (from-to)	487-495
Number of pages	9
Journal	Journal of Diabetes
Volume	10
Issue number	6
DOIs	https://doi.org/10.1111/1753-0407.12563
State	Published - Jun 2018

Bibliographical note

Funding Information:
The authors thank the research teams at all participating clinical centers, including: Christina Care Health Systems; University of California, Irvine; Long Beach Memorial Medical Center; Northwestern University; Medical University of South Carolina; Columbia University; New York Hospital Queens; St Peters’ University Hospital; University of Alabama at Birmingham; Women and Infants Hospital of Rhode Island; Fountain Valley Regional Hospital and Medical Center; and Tufts University. The authors also acknowledge the Clinical Trials & Surveys Corp. (C-TASC; Owing Mills, MD, USA), which which provided data coordination, and the Department of Laboratory Medicine and Pathology, University of Minnesota, which provided laboratory resources essential to test blood samples for biomarkers in the present study. This research was supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development intramural funding and included American Recovery and Reinvestment Act funding via contract numbers HHSN275200800013C, HHSN275200800002I, HHSN27500006, HHSN275200800003IC, HHSN27520 0800014C, HHSN275200800012C, HHSN275200800028 C, HHSN275201000009C, and HHSN275201000001Z.

Funding Information:
The authors thank the research teams at all participating clinical centers, including: Christina Care Health Systems; University of California, Irvine; Long Beach Memorial Medical Center; Northwestern University; Medical University of South Carolina; Columbia University; New York Hospital Queens; St Peters? University Hospital; University of Alabama at Birmingham; Women and Infants Hospital of Rhode Island; Fountain Valley Regional Hospital and Medical Center; and Tufts University. The authors also acknowledge the Clinical Trials & Surveys Corp. (C-TASC; Owing Mills, MD, USA), which which provided data coordination, and the Department of Laboratory Medicine and Pathology, University of Minnesota, which provided laboratory resources essential to test blood samples for biomarkers in the present study. This research was supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development intramural funding and included American Recovery and Reinvestment Act funding via contract numbers HHSN275200800013C, HHSN275200800002I, HHSN27500006, HHSN275200800003IC, HHSN275200800014C, HHSN275200800012C, HHSN275200800028C, HHSN275201000009C, and HHSN275201000001Z.

Publisher Copyright:
© 2017 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd

Keywords

cholesterol
gestational diabetes
lipids
pregnancy
triglycerides

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/1753-0407.12563

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837900

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@article{28261f5db04f4642b7c86df9547ade31,

title = "Plasma concentrations of lipids during pregnancy and the risk of gestational diabetes mellitus: A longitudinal study",

abstract = "Background: Abnormal lipid profiles have been associated with gestational diabetes mellitus (GDM), but studies with longitudinal measures of lipids throughout pregnancy are sparse. The aim of the present study was to characterize longitudinal changes in lipid profiles throughout pregnancy and prospectively examine the associations of plasma lipid concentrations with risk of GDM. Methods: This study was a nested case-control study including 107 GDM cases and 214 matched non-GDM controls from participants in the National Institute of Child Health and Human Development (NICHD) Fetal Growth Studies – Singleton cohort. Blood samples were collected longitudinally at Gestational Weeks (GW) 10–14, 15–26 (fasting sample), 23–31, and 33–39. Plasma concentrations of triglycerides, total cholesterol, and high-density lipoprotein cholesterol (HDL-C) were measured by enzymatic assays. Low-density lipoprotein cholesterol (LDL-C) was calculated using Friedewald's formula. Results: Plasma triglycerides, total cholesterol, and LDL-C increased as pregnancy progressed. At GW 10–14, the adjusted odds ratios (aORs) of GDM comparing the highest versus lowest quartile were 3.15 (95% confidence interval [CI] 1.38–7.15; P trend = 0.002) for triglycerides and 0.44 (95% CI 0.18–1.09; P trend = 0.045) for HDL-C. At GW 15–26, the aORs were 6.57 (95% CI 2.25–19.17; P trend = 0.001) for triglycerides and 0.23 (95% CI 0.08–0.63; P trend = 0.005) for HDL-C. No significant associations were observed for total cholesterol and LDL-C concentrations with risk of GDM. Conclusions: Higher plasma triglyceride and lower HDL-C concentrations in early and mid-pregnancy were significantly associated with a greater risk of GDM. Total cholesterol and LDL-C concentrations during pregnancy were not significantly associated with GDM risk.",

keywords = "cholesterol, gestational diabetes, lipids, pregnancy, triglycerides",

author = "Wei Bao and Sharon Dar and Yeyi Zhu and Jing Wu and Shristi Rawal and Shanshan Li and Weir, {Natalie L.} and Tsai, {Michael Y.} and Cuilin Zhang",

note = "Funding Information: The authors thank the research teams at all participating clinical centers, including: Christina Care Health Systems; University of California, Irvine; Long Beach Memorial Medical Center; Northwestern University; Medical University of South Carolina; Columbia University; New York Hospital Queens; St Peters{\textquoteright} University Hospital; University of Alabama at Birmingham; Women and Infants Hospital of Rhode Island; Fountain Valley Regional Hospital and Medical Center; and Tufts University. The authors also acknowledge the Clinical Trials & Surveys Corp. (C-TASC; Owing Mills, MD, USA), which which provided data coordination, and the Department of Laboratory Medicine and Pathology, University of Minnesota, which provided laboratory resources essential to test blood samples for biomarkers in the present study. This research was supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development intramural funding and included American Recovery and Reinvestment Act funding via contract numbers HHSN275200800013C, HHSN275200800002I, HHSN27500006, HHSN275200800003IC, HHSN27520 0800014C, HHSN275200800012C, HHSN275200800028 C, HHSN275201000009C, and HHSN275201000001Z. Funding Information: The authors thank the research teams at all participating clinical centers, including: Christina Care Health Systems; University of California, Irvine; Long Beach Memorial Medical Center; Northwestern University; Medical University of South Carolina; Columbia University; New York Hospital Queens; St Peters? University Hospital; University of Alabama at Birmingham; Women and Infants Hospital of Rhode Island; Fountain Valley Regional Hospital and Medical Center; and Tufts University. The authors also acknowledge the Clinical Trials & Surveys Corp. (C-TASC; Owing Mills, MD, USA), which which provided data coordination, and the Department of Laboratory Medicine and Pathology, University of Minnesota, which provided laboratory resources essential to test blood samples for biomarkers in the present study. This research was supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development intramural funding and included American Recovery and Reinvestment Act funding via contract numbers HHSN275200800013C, HHSN275200800002I, HHSN27500006, HHSN275200800003IC, HHSN275200800014C, HHSN275200800012C, HHSN275200800028C, HHSN275201000009C, and HHSN275201000001Z. Publisher Copyright: {\textcopyright} 2017 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd",

year = "2018",

month = jun,

doi = "10.1111/1753-0407.12563",

language = "English (US)",

volume = "10",

pages = "487--495",

journal = "Journal of Diabetes",

issn = "1753-0393",

publisher = "Wiley-Blackwell",

number = "6",

}

TY - JOUR

T1 - Plasma concentrations of lipids during pregnancy and the risk of gestational diabetes mellitus

T2 - A longitudinal study

AU - Bao, Wei

AU - Dar, Sharon

AU - Zhu, Yeyi

AU - Wu, Jing

AU - Rawal, Shristi

AU - Li, Shanshan

AU - Weir, Natalie L.

AU - Tsai, Michael Y.

AU - Zhang, Cuilin

N1 - Funding Information: The authors thank the research teams at all participating clinical centers, including: Christina Care Health Systems; University of California, Irvine; Long Beach Memorial Medical Center; Northwestern University; Medical University of South Carolina; Columbia University; New York Hospital Queens; St Peters’ University Hospital; University of Alabama at Birmingham; Women and Infants Hospital of Rhode Island; Fountain Valley Regional Hospital and Medical Center; and Tufts University. The authors also acknowledge the Clinical Trials & Surveys Corp. (C-TASC; Owing Mills, MD, USA), which which provided data coordination, and the Department of Laboratory Medicine and Pathology, University of Minnesota, which provided laboratory resources essential to test blood samples for biomarkers in the present study. This research was supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development intramural funding and included American Recovery and Reinvestment Act funding via contract numbers HHSN275200800013C, HHSN275200800002I, HHSN27500006, HHSN275200800003IC, HHSN27520 0800014C, HHSN275200800012C, HHSN275200800028 C, HHSN275201000009C, and HHSN275201000001Z. Funding Information: The authors thank the research teams at all participating clinical centers, including: Christina Care Health Systems; University of California, Irvine; Long Beach Memorial Medical Center; Northwestern University; Medical University of South Carolina; Columbia University; New York Hospital Queens; St Peters? University Hospital; University of Alabama at Birmingham; Women and Infants Hospital of Rhode Island; Fountain Valley Regional Hospital and Medical Center; and Tufts University. The authors also acknowledge the Clinical Trials & Surveys Corp. (C-TASC; Owing Mills, MD, USA), which which provided data coordination, and the Department of Laboratory Medicine and Pathology, University of Minnesota, which provided laboratory resources essential to test blood samples for biomarkers in the present study. This research was supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development intramural funding and included American Recovery and Reinvestment Act funding via contract numbers HHSN275200800013C, HHSN275200800002I, HHSN27500006, HHSN275200800003IC, HHSN275200800014C, HHSN275200800012C, HHSN275200800028C, HHSN275201000009C, and HHSN275201000001Z. Publisher Copyright: © 2017 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd

PY - 2018/6

Y1 - 2018/6

N2 - Background: Abnormal lipid profiles have been associated with gestational diabetes mellitus (GDM), but studies with longitudinal measures of lipids throughout pregnancy are sparse. The aim of the present study was to characterize longitudinal changes in lipid profiles throughout pregnancy and prospectively examine the associations of plasma lipid concentrations with risk of GDM. Methods: This study was a nested case-control study including 107 GDM cases and 214 matched non-GDM controls from participants in the National Institute of Child Health and Human Development (NICHD) Fetal Growth Studies – Singleton cohort. Blood samples were collected longitudinally at Gestational Weeks (GW) 10–14, 15–26 (fasting sample), 23–31, and 33–39. Plasma concentrations of triglycerides, total cholesterol, and high-density lipoprotein cholesterol (HDL-C) were measured by enzymatic assays. Low-density lipoprotein cholesterol (LDL-C) was calculated using Friedewald's formula. Results: Plasma triglycerides, total cholesterol, and LDL-C increased as pregnancy progressed. At GW 10–14, the adjusted odds ratios (aORs) of GDM comparing the highest versus lowest quartile were 3.15 (95% confidence interval [CI] 1.38–7.15; P trend = 0.002) for triglycerides and 0.44 (95% CI 0.18–1.09; P trend = 0.045) for HDL-C. At GW 15–26, the aORs were 6.57 (95% CI 2.25–19.17; P trend = 0.001) for triglycerides and 0.23 (95% CI 0.08–0.63; P trend = 0.005) for HDL-C. No significant associations were observed for total cholesterol and LDL-C concentrations with risk of GDM. Conclusions: Higher plasma triglyceride and lower HDL-C concentrations in early and mid-pregnancy were significantly associated with a greater risk of GDM. Total cholesterol and LDL-C concentrations during pregnancy were not significantly associated with GDM risk.

AB - Background: Abnormal lipid profiles have been associated with gestational diabetes mellitus (GDM), but studies with longitudinal measures of lipids throughout pregnancy are sparse. The aim of the present study was to characterize longitudinal changes in lipid profiles throughout pregnancy and prospectively examine the associations of plasma lipid concentrations with risk of GDM. Methods: This study was a nested case-control study including 107 GDM cases and 214 matched non-GDM controls from participants in the National Institute of Child Health and Human Development (NICHD) Fetal Growth Studies – Singleton cohort. Blood samples were collected longitudinally at Gestational Weeks (GW) 10–14, 15–26 (fasting sample), 23–31, and 33–39. Plasma concentrations of triglycerides, total cholesterol, and high-density lipoprotein cholesterol (HDL-C) were measured by enzymatic assays. Low-density lipoprotein cholesterol (LDL-C) was calculated using Friedewald's formula. Results: Plasma triglycerides, total cholesterol, and LDL-C increased as pregnancy progressed. At GW 10–14, the adjusted odds ratios (aORs) of GDM comparing the highest versus lowest quartile were 3.15 (95% confidence interval [CI] 1.38–7.15; P trend = 0.002) for triglycerides and 0.44 (95% CI 0.18–1.09; P trend = 0.045) for HDL-C. At GW 15–26, the aORs were 6.57 (95% CI 2.25–19.17; P trend = 0.001) for triglycerides and 0.23 (95% CI 0.08–0.63; P trend = 0.005) for HDL-C. No significant associations were observed for total cholesterol and LDL-C concentrations with risk of GDM. Conclusions: Higher plasma triglyceride and lower HDL-C concentrations in early and mid-pregnancy were significantly associated with a greater risk of GDM. Total cholesterol and LDL-C concentrations during pregnancy were not significantly associated with GDM risk.

KW - cholesterol

KW - gestational diabetes

KW - lipids

KW - pregnancy

KW - triglycerides

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ER -

Plasma concentrations of lipids during pregnancy and the risk of gestational diabetes mellitus: A longitudinal study

Abstract

Bibliographical note

Keywords

UN SDGs

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