Plasma cell neoplasms, a therapeutic approach

Brian L. McClune

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Plasma cell neoplasms represent a spectrum of diseases progressing from monoclonal gammopathy of undetermined significance (MGUS) to asymptomatic multiple myeloma (MM) to symptomatic MM. Significant advances in the management of MM continue to help increase survival and quality of life for patients. Prior to initiating treatment, diagnosis confirmation and risk stratification are crucial, particularly with transplant eligibility as that can direct initial treatment choices. Major drug classes for treating MM have included alkylating agents, anthracyclines, and corticosteroids for years, but immunomodulatory drugs (IMiDs) and proteasome inhibitors (PIs) have changed the landscape improving responses and outcomes for patients.

Original languageEnglish (US)
Title of host publicationPlasma Cell Neoplasms
Subtitle of host publicationA Morphologic, Cytogenetic and Immunophenotypic Approach
PublisherSpringer International Publishing
Pages123-141
Number of pages19
ISBN (Electronic)9783319109183
ISBN (Print)9783319109176
DOIs
StatePublished - Jan 1 2015

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