Plasma brain natriuretic peptide level after radiofrequency catheter ablation of paroxysmal, persistent, and permanent atrial fibrillation

Takumi Yamada, Yoshimasa Murakami, Taro Okada, Naoki Yoshida, Junji Toyama, Yukihiko Yoshida, Naoya Tsuboi, Yasuya Inden, Makoto Hirai, Toyoaki Murohara

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Aims: The aim of this study was to investigate the change in plasma brain natriuretic peptide (BNP) level after pulmonary vein isolation (PVI) in paroxysmal (PAF), persistent (Pers-AF), and permanent atrial fibrillation (AF) (Perm-AF) patients. Methods and results: In 96 lone AF patients (PAF = 65, Pers-AF = 17, and Perm-AF = 14), BNP was measured before and 3 months after successful PVIs. At baseline, in all patients, BNP was elevated and was significantly greater in Pers-AF and Perm-AF patients than PAF patients (P < 0.05). After 3 months of follow-up following multiple PVIs, AF recurred in 12 (18%) PAF, 7 (41%) Pers-AF, and 8 (57%) Perm-AF patients. In Pers-AF and Perm-AF patients, BNP at baseline did not predict AF recurrence. After the PVIs, BNP significantly decreased in PAF and Pers-AF patients (P = 0.005) but not in Perm-AF patients. An elevated BNP at baseline decreased to within-normal limits in all Pers-AF and Perm-AF patients without AF recurrences. In all seven (23%) patients, whose AF type improved after the PVIs, BNP decreased. Conclusion: The reduction in the BNP level after the PVI seemed to be a marker for a good outcome in AF post-ablation patients.

Original languageEnglish (US)
Pages (from-to)770-774
Number of pages5
JournalEuropace
Volume9
Issue number9
DOIs
StatePublished - Sep 2007
Externally publishedYes

Keywords

  • Atrial fibrillation
  • Brain natriuretic peptide
  • Pulmonary vein isolation
  • Radiofrequency catheter ablation

Fingerprint Dive into the research topics of 'Plasma brain natriuretic peptide level after radiofrequency catheter ablation of paroxysmal, persistent, and permanent atrial fibrillation'. Together they form a unique fingerprint.

Cite this