Plasma BIN1 correlates with heart failure and predicts arrhythmia in patients with arrhythmogenic right ventricular cardiomyopathy

Ting Ting Hong, Rebecca Cogswell, Cynthia A. James, Guson Kang, Clive R. Pullinger, Mary J. Malloy, John P. Kane, Julianne Wojciak, Hugh Calkins, Melvin M. Scheinman, Zian H. Tseng, Peter Ganz, Teresa De Marco, Daniel P. Judge, Robin M. Shaw

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Background: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a disorder involving diseased cardiac muscle. Bridging integrator 1 (BIN1) is a membrane-associated protein important to cardiomyocyte homeostasis and is downregulated in cardiomyopathy. We hypothesized that BIN1 could be released into the circulation and that blood-available BIN1 can provide useful data on the cardiac status of patients whose hearts are failing secondary to ARVC. Objective: To determine whether plasma BIN1 levels can be used to measure disease severity in patients with ARVC. Methods: We performed a retrospective cohort study of 24 patients with ARVC. Plasma BIN1 levels were assessed for their ability to correlate with cardiac functional status and predict ventricular arrhythmias. Results: Mean plasma BIN1 levels were decreased in patients with ARVC with heart failure (15 ± 7 vs 60 ± 17 in patients without heart failure, P <.05; the plasma BIN1 level was 60 ± 10 in non-ARVC normal controls). BIN1 levels correlated inversely with number of previous ventricular arrhythmia (R = -.47; P <.05), and low BIN1 levels correctly classified patients with advanced heart failure or ventricular arrhythmia (receiver operator curve area under the curve of 0.88 ± 0.07). Low BIN1 levels also predicted future ventricular arrhythmias (receiver operator curve area under the curve of 0.89 ± 0.09). In a stratified analysis, BIN1 levels could predict future arrhythmias in patients without severe heart failure (n = 20) with an accuracy of 82%. In the 7 patients with ARVC with serial blood samples, all of whom had evidence of disease progression during follow-up, plasma BIN1 levels decreased significantly (a decrease of 63%; P <.05). Conclusions: Plasma BIN1 level seems to correlate with cardiac functional status and the presence or absence of sustained ventricular arrhythmias in a small cohort of patients with ARVC and can predict future ventricular arrhythmias.

Original languageEnglish (US)
Pages (from-to)961-967
Number of pages7
JournalHeart Rhythm
Issue number6
StatePublished - Jun 2012
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by National Institutes of Health (to R.M.S.) and Cardiovascular Research Institute at University of California San Francisco (to T.T.H.).

Copyright 2013 Elsevier B.V., All rights reserved.


  • Arrhythmogenic right ventricular cardiomyopathy
  • BIN1
  • Bridging integrator 1
  • Calcium transient
  • Heart failure
  • Membrane adaptor protein
  • Ventricular arrhythmia

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