Abstract
Patients with the Lewy body variant (LBV) of Alzheimer's disease (AD) have ubiquitinated intraneuronal and neuritic accumulations of α-synuclein and show less neuron loss and tau pathology than other AD patients. Aged Tg2576 transgenic mice overexpressing human βAPP695. KM670/671NL have limited neuron loss and tau pathology, but frequent ubiquitin- and α-synuclein-positive, tau-negative neurites resembling those seen in the LBV of AD. Copyright (C) 2000 Elsevier Science B.V.
Original language | English (US) |
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Pages (from-to) | 381-383 |
Number of pages | 3 |
Journal | Brain Research |
Volume | 853 |
Issue number | 2 |
DOIs | |
State | Published - Jan 24 2000 |
Bibliographical note
Funding Information:Supported by grants from VA Merit (GMC) and NIA AG13741 (GMC) and MESC CO9680780 (KU) and NIH NS33249 (KHA). We are grateful to Elizabeth and Thomas Plott and their family for their continued support (GMC).
Keywords
- Alzheimer's
- Amyloid precursor
- Lewy
- Parkinson's
- Transgenic
- α-Synuclein