Plaque-associated α-synuclein (NACP) pathology in aged transgenic mice expressing amyloid precursor protein

Fusheng Yang, Kenji Uéda, Ping Ping Chen, Karen Hsiao Ashe, Greg M. Cole

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

Patients with the Lewy body variant (LBV) of Alzheimer's disease (AD) have ubiquitinated intraneuronal and neuritic accumulations of α-synuclein and show less neuron loss and tau pathology than other AD patients. Aged Tg2576 transgenic mice overexpressing human βAPP695. KM670/671NL have limited neuron loss and tau pathology, but frequent ubiquitin- and α-synuclein-positive, tau-negative neurites resembling those seen in the LBV of AD. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)381-383
Number of pages3
JournalBrain Research
Volume853
Issue number2
DOIs
StatePublished - Jan 24 2000

Bibliographical note

Funding Information:
Supported by grants from VA Merit (GMC) and NIA AG13741 (GMC) and MESC CO9680780 (KU) and NIH NS33249 (KHA). We are grateful to Elizabeth and Thomas Plott and their family for their continued support (GMC).

Keywords

  • Alzheimer's
  • Amyloid precursor
  • Lewy
  • Parkinson's
  • Transgenic
  • α-Synuclein

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