Plaque-associated α-synuclein (NACP) pathology in aged transgenic mice expressing amyloid precursor protein

Fusheng Yang, Kenji Uéda, Ping Ping Chen, Karen Hsiao Ashe, Greg M. Cole

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

Patients with the Lewy body variant (LBV) of Alzheimer's disease (AD) have ubiquitinated intraneuronal and neuritic accumulations of α-synuclein and show less neuron loss and tau pathology than other AD patients. Aged Tg2576 transgenic mice overexpressing human βAPP695. KM670/671NL have limited neuron loss and tau pathology, but frequent ubiquitin- and α-synuclein-positive, tau-negative neurites resembling those seen in the LBV of AD. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)381-383
Number of pages3
JournalBrain Research
Volume853
Issue number2
DOIs
StatePublished - Jan 24 2000

Keywords

  • Alzheimer's
  • Amyloid precursor
  • Lewy
  • Parkinson's
  • Transgenic
  • α-Synuclein

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