Plakinidine D, a new pyrroloacridine alkaloid from two ascidians of the genus Didemnum

C. J. Smith, D. A. Venables, C. Hopmann, C. E. Salomon, J. Jompa, A. Tahir, D. John Faulkner, C. M. Ireland

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Abstract

A previously undescribed red Didemnum sp. collected in Indonesia contained a novel pyrroloacridine, plakinidine D (4), along with the known compounds 3,5-diiodo-4-methoxyphenethylamine (5) and ascididemin (6), both of which had previously been isolated from ascidians of the genus Didemnum. Plakinidine D (4) and 3,5-diiodo-4-methoxyphenethylamine (5) were also isolated from Didemnum rubeum from the Republic of Palau. Interestingly, a collection of D. rubeum from Indonesia did not contain plakinidine D (4), but instead contained 3,5-diiodo-4-methoxyphenethylamine (5) and ascididemin (6). The structure of plakinidine D (4) was elucidated by analysis of its spectral data. Plakinidine D (4) is closely related to plakinidines A-C (1-3), previously isolated from the sponge Plakortis sp.

Original languageEnglish (US)
Pages (from-to)1048-1050
Number of pages3
JournalJournal of Natural Products
Volume60
Issue number10
DOIs
StatePublished - 1997

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