Placental transfer of ganciclovir in a woman with acquired immunodeficiency syndrome and cytomegalovirus disease

Rebecca C. Brady, Mark R. Schleiss, David P. Witte, Tariq A. Siddiqi, Peter T. Frame

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

A pregnant woman with AIDS developed cytomegalovirus (CMV) retinitis and pneumonitis, requiring intravenous ganciclovir. At 34 weeks gestation the woman delivered a 1.4-kg girl. Examination of the placenta revealed transplacental passage of CMV. Low concentrations of ganciclovir were detected in the neonate's plasma. The neonate had mild anemia but no other signs of congenital CMV infection.

Original languageEnglish (US)
Pages (from-to)796-797
Number of pages2
JournalPediatric Infectious Disease Journal
Volume21
Issue number8
DOIs
StatePublished - Aug 1 2002

Keywords

  • Acquired immunodeficiency syndrome
  • Congenital cytomegalovirus infection
  • Ganciclovir
  • Neonate

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