TY - JOUR
T1 - Placental protein 13 as an early marker for pre-eclampsia
T2 - A prospective longitudinal study
AU - Gonen, R.
AU - Shahar, R.
AU - Grimpel, Y. I.
AU - Chefetz, I.
AU - Sammar, M.
AU - Meiri, H.
AU - Gibor, Y.
PY - 2008/11
Y1 - 2008/11
N2 - Objective: To assess the value of placental protein 13 (PP13) as an early marker of pre-eclampsia. Design: Sequential blood samples were obtained from women with singleton viable pregnancies at 6-10, 16-20 and 24-28 weeks of gestation. Samples were tested for PP13 using a solid-phase sandwich enzyme-linked immunosorbent assay. Levels were expressed as multiples of the medians (MoM) of the unaffected population. The slope or rate of change in PP13 concentration per week of gestation was also calculated. Setting: Thirty-five prenatal care community clinics. Sample: In total, 1366 women were recruited, and subsequently, 20 were diagnosed with pre-eclampsia, 41 with gestational hypertension and 1178 were unaffected. Main outcome measures: Sensitivity and specificity of screening with PP13 at each gestational period and of PP13 level combined with the slope of PP13 between two testing periods. Results: At 6-10 gestational weeks, PP13 levels were significantly lower among the pre-eclampsia group with a median 0.28 MoM (95% CI 0.15-0.39, P < 0.004). Using a cutoff of 0.40 MoM, the sensitivity was 80%, false-positive rate (FPR) was 20% and odds ratio was 16.0 (95% CI 5.3-48.4). Combining MoM of 6-10 weeks and slope between 6-10 and 16-20 weeks, the sensitivity was 78%, the FPR was 6% and odds ratio was 55.5 (95% CI 18.2-169.2). The gestational hypertension group was not different from the normal group. Conclusions: PP13 in the first trimester alone or in combination with the slope between the first and the second trimesters may be a promising marker for assessing the risk of pre-eclampsia.
AB - Objective: To assess the value of placental protein 13 (PP13) as an early marker of pre-eclampsia. Design: Sequential blood samples were obtained from women with singleton viable pregnancies at 6-10, 16-20 and 24-28 weeks of gestation. Samples were tested for PP13 using a solid-phase sandwich enzyme-linked immunosorbent assay. Levels were expressed as multiples of the medians (MoM) of the unaffected population. The slope or rate of change in PP13 concentration per week of gestation was also calculated. Setting: Thirty-five prenatal care community clinics. Sample: In total, 1366 women were recruited, and subsequently, 20 were diagnosed with pre-eclampsia, 41 with gestational hypertension and 1178 were unaffected. Main outcome measures: Sensitivity and specificity of screening with PP13 at each gestational period and of PP13 level combined with the slope of PP13 between two testing periods. Results: At 6-10 gestational weeks, PP13 levels were significantly lower among the pre-eclampsia group with a median 0.28 MoM (95% CI 0.15-0.39, P < 0.004). Using a cutoff of 0.40 MoM, the sensitivity was 80%, false-positive rate (FPR) was 20% and odds ratio was 16.0 (95% CI 5.3-48.4). Combining MoM of 6-10 weeks and slope between 6-10 and 16-20 weeks, the sensitivity was 78%, the FPR was 6% and odds ratio was 55.5 (95% CI 18.2-169.2). The gestational hypertension group was not different from the normal group. Conclusions: PP13 in the first trimester alone or in combination with the slope between the first and the second trimesters may be a promising marker for assessing the risk of pre-eclampsia.
KW - Placental protein 13
KW - Pre-eclampsia
KW - Serum markers
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U2 - 10.1111/j.1471-0528.2008.01902.x
DO - 10.1111/j.1471-0528.2008.01902.x
M3 - Article
C2 - 19035985
AN - SCOPUS:53849143269
SN - 1470-0328
VL - 115
SP - 1465
EP - 1472
JO - BJOG: An International Journal of Obstetrics and Gynaecology
JF - BJOG: An International Journal of Obstetrics and Gynaecology
IS - 12
ER -