Placental Infection with Ureaplasma species is Associated with Histologic Chorioamnionitis and Adverse Outcomes in Moderately Preterm and Late-Preterm Infants

Emma L. Sweeney, Suhas G. Kallapur, Tate Gisslen, Donna S. Lambers, Claire A. Chougnet, Sally Anne Stephenson, Alan H. Jobe, Christine L. Knox

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Objective. The human Ureaplasma species are the microbes most frequently isolated from placentae of women who deliver preterm. The role of Ureaplasma species has been investigated in pregnancies at <32 weeks of gestation, but currently no studies have determined the prevalence of ureaplasmas in moderately preterm and late-preterm (hereafter, "moderate/late preterm") infants, the largest cohort of preterm infants. Methods. Women delivering moderate/late preterm infants (n = 477) and their infants/placentae (n = 535) were recruited, and swab specimens of chorioamnion tissue, chorioamnion tissue specimens, and cord blood specimens were obtained at delivery. Swab and tissue specimens were cultured and analyzed by 16S ribosomal RNA polymerase chain reaction (PCR) for the presence of microorganisms, while cord blood specimens were analyzed for the presence of cytokines, chemokines, and growth factors. Results. We detected microorganisms in 10.6% of 535 placentae (443 were delivered late preterm and 92 were delivered at term). Significantly, Ureaplasma species were the most prevalent microorganisms, and their presence alone was associated with histologically confirmed chorioamnionitis in moderate/late preterm and term placentae (P <. 001). The presence of ureaplasmas in the chorioamnion was also associated with elevated levels of granulocyte colony-stimulating factor (P =. 02). Conclusions. These findings have important implications for infection and adverse pregnancy outcomes throughout gestation and should be of major consideration for obstetricians and neonatologists.

Original languageEnglish (US)
Pages (from-to)1340-1347
Number of pages8
JournalJournal of Infectious Diseases
Volume213
Issue number8
DOIs
StatePublished - Apr 15 2016

Bibliographical note

Funding Information:
This work was supported by the National Institute of Health (grant 1R01HL097064-105956).

Keywords

  • Ureaplasma species
  • chorioamnionitis
  • cord blood
  • cytokines
  • infection
  • placenta
  • pregnancy outcomes
  • preterm birth

Fingerprint Dive into the research topics of 'Placental Infection with Ureaplasma species is Associated with Histologic Chorioamnionitis and Adverse Outcomes in Moderately Preterm and Late-Preterm Infants'. Together they form a unique fingerprint.

Cite this