Placental growth factor: What hematologists need to know

Laura F. Newell, Shernan G. Holtan

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations


Although first identified in placenta, the angiogenic factor known as placental growth factor (PlGF) can be widely expressed in ischemic or damaged tissues. Recent studies have indicated that PlGF is a relevant factor in the pathobiology of blood diseases including hemoglobinopathies and hematologic malignancies. Therapies for such blood diseases may one day be based upon these and ongoing investigations into the role of PlGF in sickle cell disease, acute and chronic leukemias, and complications related to hematopoietic cell transplantation. In this review, we summarize recent studies regarding the potential role of PlGF in blood disorders and suggest avenues for future research.

Original languageEnglish (US)
Pages (from-to)57-62
Number of pages6
JournalBlood Reviews
Issue number1
StatePublished - Jan 1 2017

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Ltd


  • Graft-versus-host disease
  • Hematopoietic cell transplantation
  • Leukemia
  • Placental growth factor
  • Sickle cell anemia


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