Although first identified in placenta, the angiogenic factor known as placental growth factor (PlGF) can be widely expressed in ischemic or damaged tissues. Recent studies have indicated that PlGF is a relevant factor in the pathobiology of blood diseases including hemoglobinopathies and hematologic malignancies. Therapies for such blood diseases may one day be based upon these and ongoing investigations into the role of PlGF in sickle cell disease, acute and chronic leukemias, and complications related to hematopoietic cell transplantation. In this review, we summarize recent studies regarding the potential role of PlGF in blood disorders and suggest avenues for future research.
Bibliographical noteFunding Information:
This work was supported in part by the Office of Research in Women's Health and the National Institute of Child Health and Human Development , Oregon BIRCWH Award Number K12HD043488 (LFN).
- Graft-versus-host disease
- Hematopoietic cell transplantation
- Placental growth factor
- Sickle cell anemia