PKMζ, a Brain-specific PKCζ Isoform, is Required for Glycolysis and Myofibroblastic Activation of Hepatic Stellate Cells

Keyphrases

• Hepatic Stellate Cells 100%
• Glycolysis 100%
• Hepatic Stellate Cell Activation 100%
• Myofibroblastic 100%
• PKC Isoforms 100%
• Plasma Membrane 50%
• Glucose Transporter 1 (GLUT1) 50%
• Vasodilator 30%
• Cancer-associated Fibroblasts 30%
• Phosphorylated Protein 30%
• Transforming Growth Factor-β 20%
• Overexpression 20%
• Transcriptome 20%
• Liver Fibrosis 20%
• Cellular Expression 20%
• Immunofluorescence 20%
• Colorectal Liver Metastases 20%
• Membrane Accumulation 20%
• Western Blotting 10%
• Protein Expression 10%
• In Cancer 10%
• Tumor 10%
• Liver 10%
• Tumor Growth 10%
• Quantitative PCR 10%
• Single-cell RNA Sequencing (scRNA-seq) 10%
• Site-directed mutagenesis 10%
• Protein Phosphorylation 10%
• Knockdown 10%
• Colorectal Tumor 10%
• Metabolic Reprogramming 10%
• Major Contributor 10%
• Short Hairpin RNA (shRNA) 10%
• TGF-1 10%
• RNA Sequencing (RNA-seq) 10%
• Glucose Uptake 10%
• Stress Testing 10%
• Seahorse 10%
• Activation Markers 10%
• Fibroblast Activation 10%
• 2-NBDG 10%
• Biotinylation 10%
• Protein Kinase Mζ (PKMζ) 10%
• Co-implantation 10%
• Metastatic Microenvironment 10%
• Cell Tumor 10%
• Pro-metastatic 10%

Biochemistry, Genetics and Molecular Biology

• Isoform 100%
• Hepatic Stellate Cell 100%
• Cell Membrane 31%
• Glucose Transporter 31%
• Cell Activation 25%
• Phosphoprotein 18%
• Fibroblast 18%
• Immunofluorescence 12%
• RNA Sequence 12%
• Cancer Growth Factor 12%
• Transcriptome 12%
• Protein Phosphorylation 6%
• Western Blot 6%
• Glucose Transport 6%
• Reprogramming 6%
• Site-Directed Mutagenesis 6%
• Murine 6%
• Seahorse 6%
• Biotinylation 6%
• Protein Kinases 6%
• Tumor Progression 6%
• Small Hairpin RNA 6%
• Serine 6%
• Fibrinogen 6%
• Reverse Transcription Polymerase Chain Reaction 6%