PKC-θ function at the immunological synapse: Prospects for therapeutic targeting

Alexandra Zanin-Zhorov, Michael L. Dustin, Bruce R. Blazar

Research output: Contribution to journalReview articlepeer-review

61 Scopus citations


Protein kinase C (PKC)-θ regulates conventional effector T (Teff) cell function. Since this initial finding, it has become clear that the role of PKC-θ in T cells is complex. PKC-θ plays a central role in Teff cell activation and survival, and negatively regulates stability of the immunological synapse (IS). Recent studies demonstrated that PKC-θ is required for the development of natural CD4 +Foxp3 + regulatory T (Treg) cells, and mediates negative regulation of Treg cell function. Here, we examine the role of PKC-θ in the IS, evidence for its distinct localization in Treg cells and the therapeutic implications of inhibiting PKC-θ in Teff cells, to reduce effector function, and in Treg cells, to increase suppressor function, for the prevention and treatment of autoimmune and alloimmune disease states.

Original languageEnglish (US)
Pages (from-to)358-363
Number of pages6
JournalTrends in Immunology
Issue number8
StatePublished - Aug 2011

Bibliographical note

Funding Information:
NIH grants PN2EY016586 (MLD), R01 HL56067, and P01 CA067493 (BRB) and Leukemia and Lymphoma Translational Research (grant R6029-07) (BRB)


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