Piperonyl butoxide as a tool in aquatic toxicological research with organophosphate insecticides

Gerald T. Ankley, Joseph R. Dierkes, Douglas A. Jensen, Gregory S. Peterson

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

Experiments were conducted to determine the effects of piperonyl butoxide, a synthetic methylenedioxyphenyl inhibitor of cytochrome(s) P450, on the toxicity of organophosphate insecticides to three cladoceran test species: Ceriodaphnia dubia, Daphnia magna, and Daphnia pulex. Coadministration of piperonyl butoxide effectively reduced the acute toxicity of four metabolically activated organophosphates (parathion, methyl parathion, diazinon, and malathion) and did not affect the toxicity of three organophosphates not requiring metabolic activation (dichlorvos, chlorfenvinphos, and mevinphos). These results indicate that piperonyl butoxide may be an effective tool in toxicological research focused upon identifying specific compounds responsible for toxicity in complex aqueous mixtures.

Original languageEnglish (US)
Pages (from-to)266-274
Number of pages9
JournalEcotoxicology and Environmental Safety
Volume21
Issue number3
DOIs
StatePublished - Jun 1991

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