Abstract
A 2-center pilot study compared clinical and laboratory outcomes in 40 patients with psoriatic arthritis before and after treatment for 8 to 24 weeks with the vitamin A derivative, etretinate. The number of tender joints fell from 22.0 ± 8.75 before treatment to 11.44 ± 8.50 after treatment (p = .000). The duration of morning stiffness was 101.95 ± 62.45 min before therapy and 44.53 ± 82.10 min after treatment (p = 0.0004). Similar highly clinically and statistically significant improvement was seen in all clinical outcome measures and in the erythrocyte sedimentation rate. Primarily mucocutaneous side effects were seen in 39/40 patients and resulted in treatment termination before 24 weeks in 9 patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 789-791 |
| Number of pages | 3 |
| Journal | Journal of Rheumatology |
| Volume | 16 |
| Issue number | 6 |
| State | Published - 1989 |
| Externally published | Yes |