Pigeon and dove eggwhite protect mice against renal infection due to P fimbriated Escherichia coli

J. R. Johnson, T. Berggren

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Pigeon and dove eggwhite exhibit high level P1 antigenic activity and are potent and specific inhibitors of adherence mediated by P fimbriae of uropathogenic Escherichia coli. To evaluate pigeon and dove eggwhite as P fimbrial receptor analogues in the prevention of ascending renal infection, mice were challenged with a P fimbriated E. coli urosepsis isolate suspended in saline alone or in saline plus various inhibitors of adherence, including D-mannose, globoside, and chicken, dove, and pigeon eggwhite. D-mannose inhibited mannose-sensitive adherence but not P fimbrial adherence, and failed to prevent renal infection. Globoside and chicken eggwhite also failed to inhibit P fimbrial adherence; chicken eggwhite had little and globoside had no impact on renal infection. In contrast, dove and pigeon eggwhite eliminated P fimbrial adherence and significantly reduced the incidence and intensity of renal infection. These findings suggest that pigeon and dove eggwhite provide P1-antigen-specific protection against ascending renal infection in mice due to P fimbriated uropathogenic E. coli.

Original languageEnglish (US)
Pages (from-to)335-339
Number of pages5
JournalAmerican Journal of the Medical Sciences
Volume307
Issue number5
DOIs
StatePublished - Jan 1 1994

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