Picomolar inhibitors of HIV reverse transcriptase featuring bicyclic replacement of a cyanovinylphenyl group

Keyphrases

• Human Immunodeficiency Virus Type 1 (HIV-1) 100%
• HIV-1 Reverse Transcriptase 100%
• IC50 Value 100%
• Bicyclol 100%
• Rilpivirine 66%
• Non-nucleoside Reverse Transcriptase Inhibitor (NNRTI) 66%
• T Cells 33%
• Wild Type Virus 33%
• Substructure 33%
• Efavirenz 33%
• FDA-approved Drugs 33%
• Catechol 33%
• Aqueous Solubility 33%
• Active Compounds 33%
• X-ray Crystal Structure 33%
• Diether 33%
• HIV-1 RT 33%
• Double mutation 33%
• Indolyl 33%
• Compound Yield 33%
• Approved Drugs 33%
• Nanomolar Activity 33%
• Structural Expectation 33%
• Indolizine Analogues 33%

Pharmacology, Toxicology and Pharmaceutical Science

• HIV 100%
• RNA Directed DNA Polymerase 100%
• EC50 75%
• Nucleoside 50%
• Rilpivirine 50%
• Efavirenz 25%
• Catechol 25%
• Boron 10 25%
• Indolizine 25%

Chemistry

• EC50 100%
• Nucleoside 66%
• Rilpivirine 66%
• Structure 33%
• Crystal Structure 33%
• Catechol 33%
• Diether 33%
• Indolizine 33%
• Efavirenz 33%