Phytotoxicity and cytotoxicity of the fumonisin C and P series of mycotoxins from Fusarium spp. fungi

H. K. Abbas; W. T. Shier; J. A. Seo; Y. W. Lee; S. M. Musser

doi:10.1016/S0041-0101(98)00115-9

Phytotoxicity and cytotoxicity of the fumonisin C and P series of mycotoxins from Fusarium spp. fungi

H. K. Abbas, W. T. Shier, J. A. Seo, Y. W. Lee, S. M. Musser

Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Fumonisin C (FC) and P (FP) are two recently identified series of sphingosine-analog mycotoxins, for which biological activities have not previously been reported. FC₁, FC₂ and OH-FC₁ (1μM) exhibited strong phytotoxicity comparable to the standard FB₁ in duckweed (Lemna pausicotata L.) cultures, whereas FC₃ and FC₄ were moderately phytotoxic. Conversely, FP₁ exhibited weak phytotoxicity only at higher concentrations (≥10μM). These mycotoxins exhibited a similar pattern of cytotoxicity with FB₁-sensitive cultured mammalian cell lines, H4TG and MDCK. Copyright (C) 1998 Elsevier Science Ltd.

Original language	English (US)
Pages (from-to)	2033-2037
Number of pages	5
Journal	Toxicon
Volume	36
Issue number	12
DOIs	https://doi.org/10.1016/S0041-0101(98)00115-9
State	Published - Dec 1998

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title = "Phytotoxicity and cytotoxicity of the fumonisin C and P series of mycotoxins from Fusarium spp. fungi",

abstract = "Fumonisin C (FC) and P (FP) are two recently identified series of sphingosine-analog mycotoxins, for which biological activities have not previously been reported. FC1, FC2 and OH-FC1 (1μM) exhibited strong phytotoxicity comparable to the standard FB1 in duckweed (Lemna pausicotata L.) cultures, whereas FC3 and FC4 were moderately phytotoxic. Conversely, FP1 exhibited weak phytotoxicity only at higher concentrations (≥10μM). These mycotoxins exhibited a similar pattern of cytotoxicity with FB1-sensitive cultured mammalian cell lines, H4TG and MDCK. Copyright (C) 1998 Elsevier Science Ltd.",

author = "Abbas, {H. K.} and Shier, {W. T.} and Seo, {J. A.} and Lee, {Y. W.} and Musser, {S. M.}",

year = "1998",

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T1 - Phytotoxicity and cytotoxicity of the fumonisin C and P series of mycotoxins from Fusarium spp. fungi

AU - Abbas, H. K.

AU - Shier, W. T.

AU - Seo, J. A.

AU - Lee, Y. W.

AU - Musser, S. M.

PY - 1998/12

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AB - Fumonisin C (FC) and P (FP) are two recently identified series of sphingosine-analog mycotoxins, for which biological activities have not previously been reported. FC1, FC2 and OH-FC1 (1μM) exhibited strong phytotoxicity comparable to the standard FB1 in duckweed (Lemna pausicotata L.) cultures, whereas FC3 and FC4 were moderately phytotoxic. Conversely, FP1 exhibited weak phytotoxicity only at higher concentrations (≥10μM). These mycotoxins exhibited a similar pattern of cytotoxicity with FB1-sensitive cultured mammalian cell lines, H4TG and MDCK. Copyright (C) 1998 Elsevier Science Ltd.

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