Phytotoxicity and cytotoxicity of the fumonisin C and P series of mycotoxins from Fusarium spp. fungi

H. K. Abbas; W. T. Shier; J. A. Seo; Y. W. Lee; S. M. Musser

doi:10.1016/S0041-0101(98)00115-9

Phytotoxicity and cytotoxicity of the fumonisin C and P series of mycotoxins from Fusarium spp. fungi

H. K. Abbas, W. T. Shier, J. A. Seo, Y. W. Lee, S. M. Musser

Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Fumonisin C (FC) and P (FP) are two recently identified series of sphingosine-analog mycotoxins, for which biological activities have not previously been reported. FC₁, FC₂ and OH-FC₁ (1μM) exhibited strong phytotoxicity comparable to the standard FB₁ in duckweed (Lemna pausicotata L.) cultures, whereas FC₃ and FC₄ were moderately phytotoxic. Conversely, FP₁ exhibited weak phytotoxicity only at higher concentrations (≥10μM). These mycotoxins exhibited a similar pattern of cytotoxicity with FB₁-sensitive cultured mammalian cell lines, H4TG and MDCK. Copyright (C) 1998 Elsevier Science Ltd.

Original language	English (US)
Pages (from-to)	2033-2037
Number of pages	5
Journal	Toxicon
Volume	36
Issue number	12
DOIs	https://doi.org/10.1016/S0041-0101(98)00115-9
State	Published - Dec 1998

Bibliographical note

Funding Information:
We thank Bobbie J. Johnson, USDA-ARS, SWSRU, Stoneville, MS for technical assistance. This research was supported in part by NRICGP research grant 96-35201-3271 from USDA.

Publisher link

10.1016/S0041-0101(98)00115-9

Find It

Find It at U of M Libraries

Cite this

@article{0f7ea60402bb4165b3b42eb6fde29659,

title = "Phytotoxicity and cytotoxicity of the fumonisin C and P series of mycotoxins from Fusarium spp. fungi",

abstract = "Fumonisin C (FC) and P (FP) are two recently identified series of sphingosine-analog mycotoxins, for which biological activities have not previously been reported. FC1, FC2 and OH-FC1 (1μM) exhibited strong phytotoxicity comparable to the standard FB1 in duckweed (Lemna pausicotata L.) cultures, whereas FC3 and FC4 were moderately phytotoxic. Conversely, FP1 exhibited weak phytotoxicity only at higher concentrations (≥10μM). These mycotoxins exhibited a similar pattern of cytotoxicity with FB1-sensitive cultured mammalian cell lines, H4TG and MDCK. Copyright (C) 1998 Elsevier Science Ltd.",

author = "Abbas, {H. K.} and Shier, {W. T.} and Seo, {J. A.} and Lee, {Y. W.} and Musser, {S. M.}",

note = "Funding Information: We thank Bobbie J. Johnson, USDA-ARS, SWSRU, Stoneville, MS for technical assistance. This research was supported in part by NRICGP research grant 96-35201-3271 from USDA.",

year = "1998",

month = dec,

doi = "10.1016/S0041-0101(98)00115-9",

language = "English (US)",

volume = "36",

pages = "2033--2037",

journal = "Toxicon",

issn = "0041-0101",

publisher = "Elsevier Limited",

number = "12",

}

TY - JOUR

T1 - Phytotoxicity and cytotoxicity of the fumonisin C and P series of mycotoxins from Fusarium spp. fungi

AU - Abbas, H. K.

AU - Shier, W. T.

AU - Seo, J. A.

AU - Lee, Y. W.

AU - Musser, S. M.

N1 - Funding Information: We thank Bobbie J. Johnson, USDA-ARS, SWSRU, Stoneville, MS for technical assistance. This research was supported in part by NRICGP research grant 96-35201-3271 from USDA.

PY - 1998/12

Y1 - 1998/12

N2 - Fumonisin C (FC) and P (FP) are two recently identified series of sphingosine-analog mycotoxins, for which biological activities have not previously been reported. FC1, FC2 and OH-FC1 (1μM) exhibited strong phytotoxicity comparable to the standard FB1 in duckweed (Lemna pausicotata L.) cultures, whereas FC3 and FC4 were moderately phytotoxic. Conversely, FP1 exhibited weak phytotoxicity only at higher concentrations (≥10μM). These mycotoxins exhibited a similar pattern of cytotoxicity with FB1-sensitive cultured mammalian cell lines, H4TG and MDCK. Copyright (C) 1998 Elsevier Science Ltd.

AB - Fumonisin C (FC) and P (FP) are two recently identified series of sphingosine-analog mycotoxins, for which biological activities have not previously been reported. FC1, FC2 and OH-FC1 (1μM) exhibited strong phytotoxicity comparable to the standard FB1 in duckweed (Lemna pausicotata L.) cultures, whereas FC3 and FC4 were moderately phytotoxic. Conversely, FP1 exhibited weak phytotoxicity only at higher concentrations (≥10μM). These mycotoxins exhibited a similar pattern of cytotoxicity with FB1-sensitive cultured mammalian cell lines, H4TG and MDCK. Copyright (C) 1998 Elsevier Science Ltd.

UR - http://www.scopus.com/inward/record.url?scp=0032403417&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032403417&partnerID=8YFLogxK

U2 - 10.1016/S0041-0101(98)00115-9

DO - 10.1016/S0041-0101(98)00115-9

M3 - Article

C2 - 9839687

AN - SCOPUS:0032403417

VL - 36

SP - 2033

EP - 2037

JO - Toxicon

JF - Toxicon

SN - 0041-0101

IS - 12

ER -

Phytotoxicity and cytotoxicity of the fumonisin C and P series of mycotoxins from Fusarium spp. fungi

Abstract

Bibliographical note

Publisher link

Find It

Other files and links

Fingerprint

Cite this