TY - JOUR
T1 - Physostigmine treatment of anticholinergic poisoning
AU - Manoguerra, Anthony S.
AU - Ruiz, Ernest
PY - 1976/2
Y1 - 1976/2
N2 - Physostigmine salicylate, a centrally acting cholinesterase inhibitor, is effective in rapidly and dramatically reversing the effects produced by anticholinergic drugs. Three case reports of successful use of physostigmine are presented. Since physostigmine is a tertiary amine that allows for passage of the drug into the central nervous system, it can reverse both the peripheral and central nervous system effects of anticholinergic poisoning. The adverse effects and contraindications of physostigmine use are discussed.
AB - Physostigmine salicylate, a centrally acting cholinesterase inhibitor, is effective in rapidly and dramatically reversing the effects produced by anticholinergic drugs. Three case reports of successful use of physostigmine are presented. Since physostigmine is a tertiary amine that allows for passage of the drug into the central nervous system, it can reverse both the peripheral and central nervous system effects of anticholinergic poisoning. The adverse effects and contraindications of physostigmine use are discussed.
KW - drug, ingestions
KW - physostigmine salicylate
KW - poisoning, anticholinergic
UR - http://www.scopus.com/inward/record.url?scp=0017262389&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017262389&partnerID=8YFLogxK
U2 - 10.1016/S0361-1124(76)80192-X
DO - 10.1016/S0361-1124(76)80192-X
M3 - Article
C2 - 933396
AN - SCOPUS:0017262389
SN - 0361-1124
VL - 5
SP - 125
EP - 127
JO - Journal of the American College of Emergency Physicians
JF - Journal of the American College of Emergency Physicians
IS - 2
ER -