Abstract
The hypothesis has been advanced that the human systemic septic response is a function of the host and not of the type of infecting organism. Metabolic and physiologic data from five immunosuppressed transplant recipients with isolated cytomegaloviral sepsis and viremia were prospectively evaluated. Serial cultures obtained from lung, sputum, urine, wound, blood, and invasive lines were positive for virus and negative for bacterial or fungal pathogens. The results were compared with two data banks derived from either victims of multiple trauma without sepsis or surgical patients with early bacterial or fungal sepsis. Statistically significant differences between the patients and the nonseptic reference group were noted for cardiac index, total peripheral resistance, arteriovenous oxygen content difference, oxygen consumption, and levels of triglycerides, proline, phenylalanine, tyrosine, α-aminobutyrate, and alanine. No such differences were present for these data compared with the septic reference group. Physiologic data obtained just before death in three patients indicated a failure of oxygen transport. It appears that the systemic septic response to viral agents is indistinguishable by physiologic and metabolic criteria from that resulting from bacterial or fungal agents.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 21-25 |
| Number of pages | 5 |
| Journal | Archives of Surgery |
| Volume | 122 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1987 |
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Physiology and Metabolism in Isolated Viral Septicemia : Further Evidence of an Organism-Independent, Host-Dependent Response. / Deutschman, Clifford Scott; Konstantinides, Frank N.; Tsai, Michael; Simmons, Richard L.; Cerra, Frank B.
In: Archives of Surgery, Vol. 122, No. 1, 01.1987, p. 21-25.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Physiology and Metabolism in Isolated Viral Septicemia
T2 - Further Evidence of an Organism-Independent, Host-Dependent Response
AU - Deutschman, Clifford Scott
AU - Konstantinides, Frank N.
AU - Tsai, Michael
AU - Simmons, Richard L.
AU - Cerra, Frank B.
PY - 1987/1
Y1 - 1987/1
N2 - The hypothesis has been advanced that the human systemic septic response is a function of the host and not of the type of infecting organism. Metabolic and physiologic data from five immunosuppressed transplant recipients with isolated cytomegaloviral sepsis and viremia were prospectively evaluated. Serial cultures obtained from lung, sputum, urine, wound, blood, and invasive lines were positive for virus and negative for bacterial or fungal pathogens. The results were compared with two data banks derived from either victims of multiple trauma without sepsis or surgical patients with early bacterial or fungal sepsis. Statistically significant differences between the patients and the nonseptic reference group were noted for cardiac index, total peripheral resistance, arteriovenous oxygen content difference, oxygen consumption, and levels of triglycerides, proline, phenylalanine, tyrosine, α-aminobutyrate, and alanine. No such differences were present for these data compared with the septic reference group. Physiologic data obtained just before death in three patients indicated a failure of oxygen transport. It appears that the systemic septic response to viral agents is indistinguishable by physiologic and metabolic criteria from that resulting from bacterial or fungal agents.
AB - The hypothesis has been advanced that the human systemic septic response is a function of the host and not of the type of infecting organism. Metabolic and physiologic data from five immunosuppressed transplant recipients with isolated cytomegaloviral sepsis and viremia were prospectively evaluated. Serial cultures obtained from lung, sputum, urine, wound, blood, and invasive lines were positive for virus and negative for bacterial or fungal pathogens. The results were compared with two data banks derived from either victims of multiple trauma without sepsis or surgical patients with early bacterial or fungal sepsis. Statistically significant differences between the patients and the nonseptic reference group were noted for cardiac index, total peripheral resistance, arteriovenous oxygen content difference, oxygen consumption, and levels of triglycerides, proline, phenylalanine, tyrosine, α-aminobutyrate, and alanine. No such differences were present for these data compared with the septic reference group. Physiologic data obtained just before death in three patients indicated a failure of oxygen transport. It appears that the systemic septic response to viral agents is indistinguishable by physiologic and metabolic criteria from that resulting from bacterial or fungal agents.
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UR - http://www.scopus.com/inward/citedby.url?scp=0023133731&partnerID=8YFLogxK
U2 - 10.1001/archsurg.1987.01400130027003
DO - 10.1001/archsurg.1987.01400130027003
M3 - Article
C2 - 3026282
AN - SCOPUS:0023133731
VL - 122
SP - 21
EP - 25
JO - JAMA Surgery
JF - JAMA Surgery
SN - 2168-6254
IS - 1
ER -