Physiological variables as markers for symptoms, risk, and interventions in heart failure

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10 Citations (Scopus)

Abstract

Heart failure is characterized by hemodynamic abnormalities, impaired exercise capacity, and shortened life - expectancy. The risk of death is influenced by a number of physiological abnormalities, the severities of which are not closely correlated. Impaired left ventricular function can be improved by vasodilator or inotropic therapy, but improvement in exercise capacity is more difficult to document. A reduction in long-term mortality has been demonstrated in response to therapy with the vasodilator combination of hydralazine and isosorbide dinitrate as well as with the converting enzyme inhibitors. The mechanism by which survival is improved is not known but appears to include a sustained increase in left ventricular ejection fraction. Prevention of progression of the syndrome will require more effective strategies to interfere with the myocardial and peripheral factors contributing to the process.

Original languageEnglish (US)
JournalCirculation
Volume87
Issue number6 SUPPL. 1
StatePublished - Jan 1 1993

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Vasodilator Agents
Heart Failure
Enzyme Inhibitors
Life Expectancy
Left Ventricular Function
Stroke Volume
Hemodynamics
Mortality
Therapeutics
isosorbide-hydralazine combination

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Physiological variables as markers for symptoms, risk, and interventions in heart failure. / Cohn, Jay N.

In: Circulation, Vol. 87, No. 6 SUPPL. 1, 01.01.1993.

Research output: Contribution to journalArticle

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