Physical and chemical characterization of a porous phosphate-modified zirconia substrate

Wes A. Schafer; Peter W Carr; E. F. Funkenbusch; K. A. Parson

doi:10.1016/0021-9673(91)85150-E

Physical and chemical characterization of a porous phosphate-modified zirconia substrate

Wes A. Schafer, Peter W Carr, E. F. Funkenbusch, K. A. Parson

Chemistry (Twin Cities)

Research output: Contribution to journal › Article › peer-review

82 Scopus citations

Abstract

A phosphate modification of previously described porous zirconium oxide high-performance liquid chromatographic support particles has been developed. Modification of the surface with inorganic phosphate alleviates the irreversible adsorption of proteins on the native oxide surface and makes the surface more biocompatible. X-ray photoelectron spectroscopic, solid-state ³¹P NMR, elemental analysis, pH stability and ³²P phosphate release studies that have been used to characterize physically the surface of these modified particles are reported.

Original language	English (US)
Pages (from-to)	137-147
Number of pages	11
Journal	Journal of Chromatography A
Volume	587
Issue number	2
DOIs	https://doi.org/10.1016/0021-9673(91)85150-E
State	Published - Dec 20 1991

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abstract = "A phosphate modification of previously described porous zirconium oxide high-performance liquid chromatographic support particles has been developed. Modification of the surface with inorganic phosphate alleviates the irreversible adsorption of proteins on the native oxide surface and makes the surface more biocompatible. X-ray photoelectron spectroscopic, solid-state 31P NMR, elemental analysis, pH stability and 32P phosphate release studies that have been used to characterize physically the surface of these modified particles are reported.",

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AU - Schafer, Wes A.

AU - Carr, Peter W

AU - Funkenbusch, E. F.

AU - Parson, K. A.

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AB - A phosphate modification of previously described porous zirconium oxide high-performance liquid chromatographic support particles has been developed. Modification of the surface with inorganic phosphate alleviates the irreversible adsorption of proteins on the native oxide surface and makes the surface more biocompatible. X-ray photoelectron spectroscopic, solid-state 31P NMR, elemental analysis, pH stability and 32P phosphate release studies that have been used to characterize physically the surface of these modified particles are reported.

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