Physical and chemical characterization of a porous phosphate-modified zirconia substrate

Wes A. Schafer; Peter W Carr; E. F. Funkenbusch; K. A. Parson

doi:10.1016/0021-9673(91)85150-E

Physical and chemical characterization of a porous phosphate-modified zirconia substrate

Wes A. Schafer, Peter W Carr, E. F. Funkenbusch, K. A. Parson

Chemistry (Twin Cities)

Research output: Contribution to journal › Article › peer-review

85 Scopus citations

Abstract

A phosphate modification of previously described porous zirconium oxide high-performance liquid chromatographic support particles has been developed. Modification of the surface with inorganic phosphate alleviates the irreversible adsorption of proteins on the native oxide surface and makes the surface more biocompatible. X-ray photoelectron spectroscopic, solid-state ³¹P NMR, elemental analysis, pH stability and ³²P phosphate release studies that have been used to characterize physically the surface of these modified particles are reported.

Original language	English (US)
Pages (from-to)	137-147
Number of pages	11
Journal	Journal of Chromatography A
Volume	587
Issue number	2
DOIs	https://doi.org/10.1016/0021-9673(91)85150-E
State	Published - Dec 20 1991

Bibliographical note

Funding Information:
The authors thank Tom Weber, John Blackwell and Dr. Alon McCormick of the University of Minnesota for many helpful discussions and information and Dr. Patrick Coleman of 3M for assistance in the 32P phosphate releases tudy. They also gratefully acknowledge financial support from 3M and the Institute for Advanced Studies in Bioprocess Technology at the University of Minnesota.

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

Publisher link

10.1016/0021-9673(91)85150-E

Find It

Find It at U of M Libraries

Cite this

@article{632118c1f3124d178844fa72e5883682,

title = "Physical and chemical characterization of a porous phosphate-modified zirconia substrate",

abstract = "A phosphate modification of previously described porous zirconium oxide high-performance liquid chromatographic support particles has been developed. Modification of the surface with inorganic phosphate alleviates the irreversible adsorption of proteins on the native oxide surface and makes the surface more biocompatible. X-ray photoelectron spectroscopic, solid-state 31P NMR, elemental analysis, pH stability and 32P phosphate release studies that have been used to characterize physically the surface of these modified particles are reported.",

author = "Schafer, {Wes A.} and Carr, {Peter W} and Funkenbusch, {E. F.} and Parson, {K. A.}",

note = "Funding Information: The authors thank Tom Weber, John Blackwell and Dr. Alon McCormick of the University of Minnesota for many helpful discussions and information and Dr. Patrick Coleman of 3M for assistance in the 32P phosphate releases tudy. They also gratefully acknowledge financial support from 3M and the Institute for Advanced Studies in Bioprocess Technology at the University of Minnesota. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1991",

month = dec,

day = "20",

doi = "10.1016/0021-9673(91)85150-E",

language = "English (US)",

volume = "587",

pages = "137--147",

journal = "Journal of Chromatography A",

issn = "0021-9673",

number = "2",

}

TY - JOUR

T1 - Physical and chemical characterization of a porous phosphate-modified zirconia substrate

AU - Schafer, Wes A.

AU - Carr, Peter W

AU - Funkenbusch, E. F.

AU - Parson, K. A.

N1 - Funding Information: The authors thank Tom Weber, John Blackwell and Dr. Alon McCormick of the University of Minnesota for many helpful discussions and information and Dr. Patrick Coleman of 3M for assistance in the 32P phosphate releases tudy. They also gratefully acknowledge financial support from 3M and the Institute for Advanced Studies in Bioprocess Technology at the University of Minnesota. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1991/12/20

Y1 - 1991/12/20

N2 - A phosphate modification of previously described porous zirconium oxide high-performance liquid chromatographic support particles has been developed. Modification of the surface with inorganic phosphate alleviates the irreversible adsorption of proteins on the native oxide surface and makes the surface more biocompatible. X-ray photoelectron spectroscopic, solid-state 31P NMR, elemental analysis, pH stability and 32P phosphate release studies that have been used to characterize physically the surface of these modified particles are reported.

AB - A phosphate modification of previously described porous zirconium oxide high-performance liquid chromatographic support particles has been developed. Modification of the surface with inorganic phosphate alleviates the irreversible adsorption of proteins on the native oxide surface and makes the surface more biocompatible. X-ray photoelectron spectroscopic, solid-state 31P NMR, elemental analysis, pH stability and 32P phosphate release studies that have been used to characterize physically the surface of these modified particles are reported.

UR - http://www.scopus.com/inward/record.url?scp=0026340930&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026340930&partnerID=8YFLogxK

U2 - 10.1016/0021-9673(91)85150-E

DO - 10.1016/0021-9673(91)85150-E

M3 - Article

AN - SCOPUS:0026340930

VL - 587

SP - 137

EP - 147

JO - Journal of Chromatography A

JF - Journal of Chromatography A

SN - 0021-9673

IS - 2

ER -

Physical and chemical characterization of a porous phosphate-modified zirconia substrate

Abstract

Bibliographical note

Publisher link

Find It

Other files and links

Fingerprint

Cite this