Abstract
A phosphate modification of previously described porous zirconium oxide high-performance liquid chromatographic support particles has been developed. Modification of the surface with inorganic phosphate alleviates the irreversible adsorption of proteins on the native oxide surface and makes the surface more biocompatible. X-ray photoelectron spectroscopic, solid-state 31P NMR, elemental analysis, pH stability and 32P phosphate release studies that have been used to characterize physically the surface of these modified particles are reported.
Original language | English (US) |
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Pages (from-to) | 137-147 |
Number of pages | 11 |
Journal | Journal of Chromatography A |
Volume | 587 |
Issue number | 2 |
DOIs | |
State | Published - Dec 20 1991 |