Physical Activity, Fitness, and Cardiometabolic Risk Factors in Adult Survivors of Childhood Cancer with a History of Hematopoietic Cell Transplantation

Megan E. Slater, Julia Steinberger, Julie A. Ross, Aaron S. Kelly, Eric J. Chow, Ildiko H. Koves, Paul Hoffmeister, Alan R. Sinaiko, Anna Petryk, Antoinette Moran, Jill Lee, Lisa S. Chow, K. Scott Baker

Research output: Contribution to journalArticle

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Abstract

Along with other childhood cancer survivors (CCS), hematopoietic cell transplantation (HCT) survivors are at high risk of treatment-related late effects, including cardiovascular disease and diabetes. Cardiometabolic risk factor abnormalities may be exacerbated by inadequate physical activity (PA). Relationships between PA and cardiometabolic risk factors have not been well described in CCS with HCT. PA (self reported), mobility (timed up and go test), endurance (6-minute walk test), handgrip strength, and cardiometabolic risk factors were measured in 119 HCT survivors and 66 sibling controls ages ≥18 years. Adjusted comparisons between HCT survivors and controls and between categories of low and high PA, mobility, endurance, and strength were performed with linear regression. Among HCT survivors, the high PA group had lower waist circumference (WC) (81.9 ± 2.5 versus 88.6 ± 3.1 cm ± standard error (SE), P= .009) than the low PA group, whereas the high endurance group had lower WC (77.8 ± 2.6 versus 87.8 ± 2.5 cm ± SE, P= .0001) and percent fat mass (33.6 ± 1.8 versus 39.4 ± 1.7% ± SE, P= .0008) and greater insulin sensitivity (IS) (10.9 ± 1.0 versus 7.42 ± 1.14 mg/kg/min ± SE via euglycemic insulin clamp, P= .001) than the low endurance group. Differences were greater in HCT survivors than in controls for WC between low and high PA groups, triglycerides between low and high mobility groups, and WC, systolic blood pressure, and IS between low and high endurance groups (all Pinteraction <.05). Higher endurance was associated with a more favorable cardiometabolic profile in HCT survivors, suggesting that interventions directed to increase endurance in survivors may reduce the risk of future cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)1278-1283
Number of pages6
JournalBiology of Blood and Marrow Transplantation
Volume21
Issue number7
DOIs
StatePublished - Jul 1 2015

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Physical Fitness
Cell Transplantation
Survivors
Exercise
Waist Circumference
Neoplasms
Insulin Resistance
Cardiovascular Diseases
Blood Pressure
Glucose Clamp Technique
Siblings
Linear Models
Triglycerides
Fats
Insulin

Keywords

  • Cardiometabolic risk
  • Childhood cancer survivors
  • Endurance
  • Hematopoietic cell transplantation
  • Physical activity

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Physical Activity, Fitness, and Cardiometabolic Risk Factors in Adult Survivors of Childhood Cancer with a History of Hematopoietic Cell Transplantation. / Slater, Megan E.; Steinberger, Julia; Ross, Julie A.; Kelly, Aaron S.; Chow, Eric J.; Koves, Ildiko H.; Hoffmeister, Paul; Sinaiko, Alan R.; Petryk, Anna; Moran, Antoinette; Lee, Jill; Chow, Lisa S.; Baker, K. Scott.

In: Biology of Blood and Marrow Transplantation, Vol. 21, No. 7, 01.07.2015, p. 1278-1283.

Research output: Contribution to journalArticle

Slater, Megan E. ; Steinberger, Julia ; Ross, Julie A. ; Kelly, Aaron S. ; Chow, Eric J. ; Koves, Ildiko H. ; Hoffmeister, Paul ; Sinaiko, Alan R. ; Petryk, Anna ; Moran, Antoinette ; Lee, Jill ; Chow, Lisa S. ; Baker, K. Scott. / Physical Activity, Fitness, and Cardiometabolic Risk Factors in Adult Survivors of Childhood Cancer with a History of Hematopoietic Cell Transplantation. In: Biology of Blood and Marrow Transplantation. 2015 ; Vol. 21, No. 7. pp. 1278-1283.
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