Physical activity and individual plasma phospholipid SFAs in pregnancy: a longitudinal study in a multiracial/multiethnic cohort in the United States

Xinyue Liu; Liwei Chen; Zhe Fei; Sifang K. Zhao; Yeyi Zhu; Tong Xia; Jin Dai; Mohammad L. Rahman; Jing Wu; Natalie L. Weir; Michael Y. Tsai; Cuilin Zhang

doi:10.1093/ajcn/nqac250

Physical activity and individual plasma phospholipid SFAs in pregnancy: a longitudinal study in a multiracial/multiethnic cohort in the United States

Xinyue Liu, Liwei Chen, Zhe Fei, Sifang K. Zhao, Yeyi Zhu, Tong Xia, Jin Dai, Mohammad L. Rahman, Jing Wu, Natalie L. Weir, Michael Y. Tsai, Cuilin Zhang

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Circulating individual SFAs in pregnant females are critical for maternal and fetal health. However, research on identifying their modifiable factors is limited. Objectives: We aimed to examine the associations of total physical activity (PA) and types of PA with circulating individual SFAs during pregnancy in a multiracial/multiethnic cohort of pregnant females in the United States. Methods: The study included participants in a nested case–control study (n = 321) from the Eunice Kennedy Shriver NICHD Fetal Growth Studies–Singleton Cohort. Sampling weights were applied, so the results represented the entire Fetal Growth Cohort. Plasma phospholipid SFAs were measured at 4 visits [10–14 (visit 1), 15–26 (visit 2), 23–31 (visit 3), and 33–39 (visit 4) weeks of gestation] throughout pregnancy. PA of the previous year at visit 1 and since the previous visit at the subsequent visits was assessed using the validated Pregnancy PA Questionnaire. Time-specific and longitudinal associations were examined using multivariable linear and generalized estimating equation models. Results: Total PA (metabolic equivalent of task-h/wk) was positively associated with circulating heptadecanoic acid (17:0) at visit 1 (β × 10³: 0.07; 95% CI: 0.02, 0.11) and pentadecanoic acid (15:0) at visit 3 (β × 10³: 0.09; 95% CI: 0.03, 0.14) independent of sociodemographic, reproductive, pregnancy, and dietary factors. Across the 4 visits, the positive associations with total PA were consistent for pentadecanoic acid (β × 10³: 0.06; 95% CI: 0.02, 0.10) and heptadecanoic acid (β × 10³: 0.10; 95% CI: 0.06, 0.14). Out of the 4 PA types (i.e., sports/exercise, household/caregiving, transportation, and occupational PA) considered, the magnitude of positive associations was the largest for sports/exercise PA. Conclusions: Our findings suggest that maternal PA is positively associated with circulating pentadecanoic and heptadecanoic acids. The findings warrant confirmation by future studies. This trial was registered at clinicaltrials.gov as NCT00912132.

Original language	English (US)
Pages (from-to)	1729-1737
Number of pages	9
Journal	American Journal of Clinical Nutrition
Volume	116
Issue number	6
DOIs	https://doi.org/10.1093/ajcn/nqac250
State	Published - Dec 2022

Bibliographical note

Funding Information:
The authors’ responsibilities were as follows—XL, LC, and CZ: designed the research and had primary responsibility for the final content; CZ: supervised data collection and obtained funding; NLW and MYT: led the laboratory testing; SKZ, YZ, MLR, JW, NLW, and MYT: contributed to data interpretation; XL, LC, ZF, TX, and JD: analyzed data or performed statistical analysis; XL and LC: wrote the paper; and all authors: revised and edited the manuscript and read and approved the final manuscript. The data, along with a set of guidelines for researchers applying for the data, will be posted to a data-sharing site, NICHD Data and Specimen Hub (DASH) [ https://dash.nichd.nih.gov/]. Supported by Eunice Kennedy Shriver NICHD intramural funding including American Recovery and Reinvestment Act funding via contract numbers HHSN275200800013C, HHSN275200800002I, HHSN27500006, HHSN275200800003IC, HHSN275200800014C, HHSN275200800012C, HHSN275200800028C, HHSN275201000009C, and HHSN275201000001Z (to CZ); NICHD grant R01HD082311 (to LC); NIDDK grant K01DK120807 (to YZ); and the Pilot Project Research Training Program of the Southern California National Institute for Occupational Safety and Health Education and Research Center (SCERC), via CDC grant T42 OH008412 (to XL). The contents of this article are solely the responsibility of the authors and do not necessarily represent the official view of the CDC. Author disclosures: The authors report no conflicts of interest. Supplemental Figure 1 and Supplemental Tables 1–5 are available from the “Supplementary data” link in the online posting of the article and from the same link in the online table of contents at https://academic.oup.com/ajcn/.

Funding Information:
Supported by Eunice Kennedy Shriver NICHD intramural funding including American Recovery and Reinvestment Act funding via contract numbers HHSN275200800013C, HHSN275200800002I, HHSN27500006, HHSN275200800003IC, HHSN275200800014C, HHSN275200800012C, HHSN275200800028C, HHSN275201000009C, and HHSN275201000001Z (to CZ); NICHD grant R01HD082311 (to LC); NIDDK grant K01DK120807 (to YZ); and the Pilot Project Research Training Program of the Southern California National Institute for Occupational Safety and Health Education and Research Center (SCERC), via CDC grant T42 OH008412 (to XL). The contents of this article are solely the responsibility of the authors and do not necessarily represent the official view of the CDC.

Publisher Copyright:
© 2022 American Society for Nutrition.

Keywords

PA
SFAs
maternal exercise
physical activity
pregnancy health
pregnant females
prospective cohort
saturated fatty acids

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/ajcn/nqac250

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Liu, X., Chen, L., Fei, Z., Zhao, S. K., Zhu, Y., Xia, T., Dai, J., Rahman, M. L., Wu, J., Weir, N. L., Tsai, M. Y., & Zhang, C. (2022). Physical activity and individual plasma phospholipid SFAs in pregnancy: a longitudinal study in a multiracial/multiethnic cohort in the United States. American Journal of Clinical Nutrition, 116(6), 1729-1737. https://doi.org/10.1093/ajcn/nqac250

Liu, X, Chen, L, Fei, Z, Zhao, SK, Zhu, Y, Xia, T, Dai, J, Rahman, ML, Wu, J, Weir, NL , Tsai, MY & Zhang, C 2022, 'Physical activity and individual plasma phospholipid SFAs in pregnancy: a longitudinal study in a multiracial/multiethnic cohort in the United States', American Journal of Clinical Nutrition, vol. 116, no. 6, pp. 1729-1737. https://doi.org/10.1093/ajcn/nqac250

@article{ce7cc60a0f4e40cfb8f9990bc438dcab,

title = "Physical activity and individual plasma phospholipid SFAs in pregnancy: a longitudinal study in a multiracial/multiethnic cohort in the United States",

abstract = "Background: Circulating individual SFAs in pregnant females are critical for maternal and fetal health. However, research on identifying their modifiable factors is limited. Objectives: We aimed to examine the associations of total physical activity (PA) and types of PA with circulating individual SFAs during pregnancy in a multiracial/multiethnic cohort of pregnant females in the United States. Methods: The study included participants in a nested case–control study (n = 321) from the Eunice Kennedy Shriver NICHD Fetal Growth Studies–Singleton Cohort. Sampling weights were applied, so the results represented the entire Fetal Growth Cohort. Plasma phospholipid SFAs were measured at 4 visits [10–14 (visit 1), 15–26 (visit 2), 23–31 (visit 3), and 33–39 (visit 4) weeks of gestation] throughout pregnancy. PA of the previous year at visit 1 and since the previous visit at the subsequent visits was assessed using the validated Pregnancy PA Questionnaire. Time-specific and longitudinal associations were examined using multivariable linear and generalized estimating equation models. Results: Total PA (metabolic equivalent of task-h/wk) was positively associated with circulating heptadecanoic acid (17:0) at visit 1 (β × 103: 0.07; 95% CI: 0.02, 0.11) and pentadecanoic acid (15:0) at visit 3 (β × 103: 0.09; 95% CI: 0.03, 0.14) independent of sociodemographic, reproductive, pregnancy, and dietary factors. Across the 4 visits, the positive associations with total PA were consistent for pentadecanoic acid (β × 103: 0.06; 95% CI: 0.02, 0.10) and heptadecanoic acid (β × 103: 0.10; 95% CI: 0.06, 0.14). Out of the 4 PA types (i.e., sports/exercise, household/caregiving, transportation, and occupational PA) considered, the magnitude of positive associations was the largest for sports/exercise PA. Conclusions: Our findings suggest that maternal PA is positively associated with circulating pentadecanoic and heptadecanoic acids. The findings warrant confirmation by future studies. This trial was registered at clinicaltrials.gov as NCT00912132.",

keywords = "PA, SFAs, maternal exercise, physical activity, pregnancy health, pregnant females, prospective cohort, saturated fatty acids",

author = "Xinyue Liu and Liwei Chen and Zhe Fei and Zhao, {Sifang K.} and Yeyi Zhu and Tong Xia and Jin Dai and Rahman, {Mohammad L.} and Jing Wu and Weir, {Natalie L.} and Tsai, {Michael Y.} and Cuilin Zhang",

note = "Funding Information: The authors{\textquoteright} responsibilities were as follows—XL, LC, and CZ: designed the research and had primary responsibility for the final content; CZ: supervised data collection and obtained funding; NLW and MYT: led the laboratory testing; SKZ, YZ, MLR, JW, NLW, and MYT: contributed to data interpretation; XL, LC, ZF, TX, and JD: analyzed data or performed statistical analysis; XL and LC: wrote the paper; and all authors: revised and edited the manuscript and read and approved the final manuscript. The data, along with a set of guidelines for researchers applying for the data, will be posted to a data-sharing site, NICHD Data and Specimen Hub (DASH) [ https://dash.nichd.nih.gov/]. Supported by Eunice Kennedy Shriver NICHD intramural funding including American Recovery and Reinvestment Act funding via contract numbers HHSN275200800013C, HHSN275200800002I, HHSN27500006, HHSN275200800003IC, HHSN275200800014C, HHSN275200800012C, HHSN275200800028C, HHSN275201000009C, and HHSN275201000001Z (to CZ); NICHD grant R01HD082311 (to LC); NIDDK grant K01DK120807 (to YZ); and the Pilot Project Research Training Program of the Southern California National Institute for Occupational Safety and Health Education and Research Center (SCERC), via CDC grant T42 OH008412 (to XL). The contents of this article are solely the responsibility of the authors and do not necessarily represent the official view of the CDC. Author disclosures: The authors report no conflicts of interest. Supplemental Figure 1 and Supplemental Tables 1–5 are available from the “Supplementary data” link in the online posting of the article and from the same link in the online table of contents at https://academic.oup.com/ajcn/. Funding Information: Supported by Eunice Kennedy Shriver NICHD intramural funding including American Recovery and Reinvestment Act funding via contract numbers HHSN275200800013C, HHSN275200800002I, HHSN27500006, HHSN275200800003IC, HHSN275200800014C, HHSN275200800012C, HHSN275200800028C, HHSN275201000009C, and HHSN275201000001Z (to CZ); NICHD grant R01HD082311 (to LC); NIDDK grant K01DK120807 (to YZ); and the Pilot Project Research Training Program of the Southern California National Institute for Occupational Safety and Health Education and Research Center (SCERC), via CDC grant T42 OH008412 (to XL). The contents of this article are solely the responsibility of the authors and do not necessarily represent the official view of the CDC. Publisher Copyright: {\textcopyright} 2022 American Society for Nutrition.",

year = "2022",

month = dec,

doi = "10.1093/ajcn/nqac250",

language = "English (US)",

volume = "116",

pages = "1729--1737",

journal = "American Journal of Clinical Nutrition",

issn = "0002-9165",

publisher = "Elsevier B.V.",

number = "6",

}

TY - JOUR

T1 - Physical activity and individual plasma phospholipid SFAs in pregnancy

T2 - a longitudinal study in a multiracial/multiethnic cohort in the United States

AU - Liu, Xinyue

AU - Chen, Liwei

AU - Fei, Zhe

AU - Zhao, Sifang K.

AU - Zhu, Yeyi

AU - Xia, Tong

AU - Dai, Jin

AU - Rahman, Mohammad L.

AU - Wu, Jing

AU - Weir, Natalie L.

AU - Tsai, Michael Y.

AU - Zhang, Cuilin

N1 - Funding Information: The authors’ responsibilities were as follows—XL, LC, and CZ: designed the research and had primary responsibility for the final content; CZ: supervised data collection and obtained funding; NLW and MYT: led the laboratory testing; SKZ, YZ, MLR, JW, NLW, and MYT: contributed to data interpretation; XL, LC, ZF, TX, and JD: analyzed data or performed statistical analysis; XL and LC: wrote the paper; and all authors: revised and edited the manuscript and read and approved the final manuscript. The data, along with a set of guidelines for researchers applying for the data, will be posted to a data-sharing site, NICHD Data and Specimen Hub (DASH) [ https://dash.nichd.nih.gov/]. Supported by Eunice Kennedy Shriver NICHD intramural funding including American Recovery and Reinvestment Act funding via contract numbers HHSN275200800013C, HHSN275200800002I, HHSN27500006, HHSN275200800003IC, HHSN275200800014C, HHSN275200800012C, HHSN275200800028C, HHSN275201000009C, and HHSN275201000001Z (to CZ); NICHD grant R01HD082311 (to LC); NIDDK grant K01DK120807 (to YZ); and the Pilot Project Research Training Program of the Southern California National Institute for Occupational Safety and Health Education and Research Center (SCERC), via CDC grant T42 OH008412 (to XL). The contents of this article are solely the responsibility of the authors and do not necessarily represent the official view of the CDC. Author disclosures: The authors report no conflicts of interest. Supplemental Figure 1 and Supplemental Tables 1–5 are available from the “Supplementary data” link in the online posting of the article and from the same link in the online table of contents at https://academic.oup.com/ajcn/. Funding Information: Supported by Eunice Kennedy Shriver NICHD intramural funding including American Recovery and Reinvestment Act funding via contract numbers HHSN275200800013C, HHSN275200800002I, HHSN27500006, HHSN275200800003IC, HHSN275200800014C, HHSN275200800012C, HHSN275200800028C, HHSN275201000009C, and HHSN275201000001Z (to CZ); NICHD grant R01HD082311 (to LC); NIDDK grant K01DK120807 (to YZ); and the Pilot Project Research Training Program of the Southern California National Institute for Occupational Safety and Health Education and Research Center (SCERC), via CDC grant T42 OH008412 (to XL). The contents of this article are solely the responsibility of the authors and do not necessarily represent the official view of the CDC. Publisher Copyright: © 2022 American Society for Nutrition.

PY - 2022/12

Y1 - 2022/12

N2 - Background: Circulating individual SFAs in pregnant females are critical for maternal and fetal health. However, research on identifying their modifiable factors is limited. Objectives: We aimed to examine the associations of total physical activity (PA) and types of PA with circulating individual SFAs during pregnancy in a multiracial/multiethnic cohort of pregnant females in the United States. Methods: The study included participants in a nested case–control study (n = 321) from the Eunice Kennedy Shriver NICHD Fetal Growth Studies–Singleton Cohort. Sampling weights were applied, so the results represented the entire Fetal Growth Cohort. Plasma phospholipid SFAs were measured at 4 visits [10–14 (visit 1), 15–26 (visit 2), 23–31 (visit 3), and 33–39 (visit 4) weeks of gestation] throughout pregnancy. PA of the previous year at visit 1 and since the previous visit at the subsequent visits was assessed using the validated Pregnancy PA Questionnaire. Time-specific and longitudinal associations were examined using multivariable linear and generalized estimating equation models. Results: Total PA (metabolic equivalent of task-h/wk) was positively associated with circulating heptadecanoic acid (17:0) at visit 1 (β × 103: 0.07; 95% CI: 0.02, 0.11) and pentadecanoic acid (15:0) at visit 3 (β × 103: 0.09; 95% CI: 0.03, 0.14) independent of sociodemographic, reproductive, pregnancy, and dietary factors. Across the 4 visits, the positive associations with total PA were consistent for pentadecanoic acid (β × 103: 0.06; 95% CI: 0.02, 0.10) and heptadecanoic acid (β × 103: 0.10; 95% CI: 0.06, 0.14). Out of the 4 PA types (i.e., sports/exercise, household/caregiving, transportation, and occupational PA) considered, the magnitude of positive associations was the largest for sports/exercise PA. Conclusions: Our findings suggest that maternal PA is positively associated with circulating pentadecanoic and heptadecanoic acids. The findings warrant confirmation by future studies. This trial was registered at clinicaltrials.gov as NCT00912132.

AB - Background: Circulating individual SFAs in pregnant females are critical for maternal and fetal health. However, research on identifying their modifiable factors is limited. Objectives: We aimed to examine the associations of total physical activity (PA) and types of PA with circulating individual SFAs during pregnancy in a multiracial/multiethnic cohort of pregnant females in the United States. Methods: The study included participants in a nested case–control study (n = 321) from the Eunice Kennedy Shriver NICHD Fetal Growth Studies–Singleton Cohort. Sampling weights were applied, so the results represented the entire Fetal Growth Cohort. Plasma phospholipid SFAs were measured at 4 visits [10–14 (visit 1), 15–26 (visit 2), 23–31 (visit 3), and 33–39 (visit 4) weeks of gestation] throughout pregnancy. PA of the previous year at visit 1 and since the previous visit at the subsequent visits was assessed using the validated Pregnancy PA Questionnaire. Time-specific and longitudinal associations were examined using multivariable linear and generalized estimating equation models. Results: Total PA (metabolic equivalent of task-h/wk) was positively associated with circulating heptadecanoic acid (17:0) at visit 1 (β × 103: 0.07; 95% CI: 0.02, 0.11) and pentadecanoic acid (15:0) at visit 3 (β × 103: 0.09; 95% CI: 0.03, 0.14) independent of sociodemographic, reproductive, pregnancy, and dietary factors. Across the 4 visits, the positive associations with total PA were consistent for pentadecanoic acid (β × 103: 0.06; 95% CI: 0.02, 0.10) and heptadecanoic acid (β × 103: 0.10; 95% CI: 0.06, 0.14). Out of the 4 PA types (i.e., sports/exercise, household/caregiving, transportation, and occupational PA) considered, the magnitude of positive associations was the largest for sports/exercise PA. Conclusions: Our findings suggest that maternal PA is positively associated with circulating pentadecanoic and heptadecanoic acids. The findings warrant confirmation by future studies. This trial was registered at clinicaltrials.gov as NCT00912132.

KW - PA

KW - SFAs

KW - maternal exercise

KW - physical activity

KW - pregnancy health

KW - pregnant females

KW - prospective cohort

KW - saturated fatty acids

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U2 - 10.1093/ajcn/nqac250

DO - 10.1093/ajcn/nqac250

M3 - Article

C2 - 36373403

AN - SCOPUS:85144589765

SN - 0002-9165

VL - 116

SP - 1729

EP - 1737

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

IS - 6

ER -

Physical activity and individual plasma phospholipid SFAs in pregnancy: a longitudinal study in a multiracial/multiethnic cohort in the United States

Abstract

Bibliographical note

Keywords

UN SDGs

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