Phylogeographic analysis of foot-and-mouth disease virus serotype O dispersal and associated drivers in East Africa

Anna Munsey; Frank Norbert Mwiine; Sylvester Ochwo; Lauro Velazquez-Salinas; Zaheer Ahmed; Francois Maree; Luis L. Rodriguez; Elizabeth Rieder; Andres Perez; Simon Dellicour; Kimberly VanderWaal

doi:10.1111/mec.15991

Phylogeographic analysis of foot-and-mouth disease virus serotype O dispersal and associated drivers in East Africa

Anna Munsey, Frank Norbert Mwiine, Sylvester Ochwo, Lauro Velazquez-Salinas, Zaheer Ahmed, Francois Maree, Luis L. Rodriguez, Elizabeth Rieder, Andres Perez, Simon Dellicour, Kimberly VanderWaal

Veterinary Population Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The continued endemicity of foot and mouth disease virus (FMDV) in East Africa has significant implications for livestock production and poverty reduction, yet its complex epidemiology in endemic settings remains poorly understood. Identifying FMDV dispersal routes and drivers of transmission is key to improved control strategies. Environmental heterogeneity and anthropogenic drivers (e.g., demand for animal products) can impact viral spread by influencing host movements. Here, we utilized FMDV serotype O VP1 genetic sequences and corresponding spatiotemporal data in order to (i) infer the recent dispersal history, and (II) investigate the impact of external factors (cattle density, human population density, proximity to livestock markets, and drought) on dispersal velocity, location, and direction of FMDV serotype O in East Africa. We identified statistical evidence of long-distance transmission events, and we found that FMDV serotype O tends to remain circulating in areas of high cattle density, high human population density, and in close proximity to livestock markets. The latter two findings highlight the influence of anthropogenic factors on FMDV serotype O spread in this region. These findings contribute to the understanding of FMDV epidemiology in East Africa and can help guide improved control measures.

Original language	English (US)
Pages (from-to)	3815-3825
Number of pages	11
Journal	Molecular ecology
Volume	30
Issue number	15
Early online date	May 19 2021
DOIs	https://doi.org/10.1111/mec.15991
State	Published - Aug 2021

Bibliographical note

Funding Information:
Cooperative Biological Engagement Program of the United States Department of Defense, Defense Threat Reduction Agency [agreement #8802]; Agricultural Research Service, United States Department of Agriculture [CRIS project #1940-32000-061-00D]; AM was supported by the National Institute of Food and Agriculture, United States Department of Agriculture [grant #2016-38420-25288]. SD is supported by the Fonds National de la Recherche Scientifique (FNRS, Belgium) The authors thank Shinichiro Maruyama for assistance with TreeTrimmer and Ehud (Udi) Elnekave for assistance with the beast analysis.

Funding Information:
Cooperative Biological Engagement Program of the United States Department of Defense, Defense Threat Reduction Agency [agreement #8802]; Agricultural Research Service, United States Department of Agriculture [CRIS project #1940‐32000‐061‐00D]; AM was supported by the National Institute of Food and Agriculture, United States Department of Agriculture [grant #2016‐38420‐25288]. SD is supported by the Fonds National de la Recherche Scientifique (FNRS, Belgium)

Publisher Copyright:
© 2021 John Wiley & Sons Ltd

Keywords

Bayesian inference
disease ecology
environmental factors
landscape phylogeography
molecular epidemiology
spatial analysis

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/mec.15991

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title = "Phylogeographic analysis of foot-and-mouth disease virus serotype O dispersal and associated drivers in East Africa",

abstract = "The continued endemicity of foot and mouth disease virus (FMDV) in East Africa has significant implications for livestock production and poverty reduction, yet its complex epidemiology in endemic settings remains poorly understood. Identifying FMDV dispersal routes and drivers of transmission is key to improved control strategies. Environmental heterogeneity and anthropogenic drivers (e.g., demand for animal products) can impact viral spread by influencing host movements. Here, we utilized FMDV serotype O VP1 genetic sequences and corresponding spatiotemporal data in order to (i) infer the recent dispersal history, and (II) investigate the impact of external factors (cattle density, human population density, proximity to livestock markets, and drought) on dispersal velocity, location, and direction of FMDV serotype O in East Africa. We identified statistical evidence of long-distance transmission events, and we found that FMDV serotype O tends to remain circulating in areas of high cattle density, high human population density, and in close proximity to livestock markets. The latter two findings highlight the influence of anthropogenic factors on FMDV serotype O spread in this region. These findings contribute to the understanding of FMDV epidemiology in East Africa and can help guide improved control measures.",

keywords = "Bayesian inference, disease ecology, environmental factors, landscape phylogeography, molecular epidemiology, spatial analysis",

author = "Anna Munsey and Mwiine, {Frank Norbert} and Sylvester Ochwo and Lauro Velazquez-Salinas and Zaheer Ahmed and Francois Maree and Rodriguez, {Luis L.} and Elizabeth Rieder and Andres Perez and Simon Dellicour and Kimberly VanderWaal",

note = "Funding Information: Cooperative Biological Engagement Program of the United States Department of Defense, Defense Threat Reduction Agency [agreement #8802]; Agricultural Research Service, United States Department of Agriculture [CRIS project #1940-32000-061-00D]; AM was supported by the National Institute of Food and Agriculture, United States Department of Agriculture [grant #2016-38420-25288]. SD is supported by the Fonds National de la Recherche Scientifique (FNRS, Belgium) The authors thank Shinichiro Maruyama for assistance with TreeTrimmer and Ehud (Udi) Elnekave for assistance with the beast analysis. Funding Information: Cooperative Biological Engagement Program of the United States Department of Defense, Defense Threat Reduction Agency [agreement #8802]; Agricultural Research Service, United States Department of Agriculture [CRIS project #1940‐32000‐061‐00D]; AM was supported by the National Institute of Food and Agriculture, United States Department of Agriculture [grant #2016‐38420‐25288]. SD is supported by the Fonds National de la Recherche Scientifique (FNRS, Belgium) Publisher Copyright: {\textcopyright} 2021 John Wiley & Sons Ltd",

year = "2021",

month = aug,

doi = "10.1111/mec.15991",

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AU - Munsey, Anna

AU - Mwiine, Frank Norbert

AU - Ochwo, Sylvester

AU - Velazquez-Salinas, Lauro

AU - Ahmed, Zaheer

AU - Maree, Francois

AU - Rodriguez, Luis L.

AU - Rieder, Elizabeth

AU - Perez, Andres

AU - Dellicour, Simon

AU - VanderWaal, Kimberly

N1 - Funding Information: Cooperative Biological Engagement Program of the United States Department of Defense, Defense Threat Reduction Agency [agreement #8802]; Agricultural Research Service, United States Department of Agriculture [CRIS project #1940-32000-061-00D]; AM was supported by the National Institute of Food and Agriculture, United States Department of Agriculture [grant #2016-38420-25288]. SD is supported by the Fonds National de la Recherche Scientifique (FNRS, Belgium) The authors thank Shinichiro Maruyama for assistance with TreeTrimmer and Ehud (Udi) Elnekave for assistance with the beast analysis. Funding Information: Cooperative Biological Engagement Program of the United States Department of Defense, Defense Threat Reduction Agency [agreement #8802]; Agricultural Research Service, United States Department of Agriculture [CRIS project #1940‐32000‐061‐00D]; AM was supported by the National Institute of Food and Agriculture, United States Department of Agriculture [grant #2016‐38420‐25288]. SD is supported by the Fonds National de la Recherche Scientifique (FNRS, Belgium) Publisher Copyright: © 2021 John Wiley & Sons Ltd

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N2 - The continued endemicity of foot and mouth disease virus (FMDV) in East Africa has significant implications for livestock production and poverty reduction, yet its complex epidemiology in endemic settings remains poorly understood. Identifying FMDV dispersal routes and drivers of transmission is key to improved control strategies. Environmental heterogeneity and anthropogenic drivers (e.g., demand for animal products) can impact viral spread by influencing host movements. Here, we utilized FMDV serotype O VP1 genetic sequences and corresponding spatiotemporal data in order to (i) infer the recent dispersal history, and (II) investigate the impact of external factors (cattle density, human population density, proximity to livestock markets, and drought) on dispersal velocity, location, and direction of FMDV serotype O in East Africa. We identified statistical evidence of long-distance transmission events, and we found that FMDV serotype O tends to remain circulating in areas of high cattle density, high human population density, and in close proximity to livestock markets. The latter two findings highlight the influence of anthropogenic factors on FMDV serotype O spread in this region. These findings contribute to the understanding of FMDV epidemiology in East Africa and can help guide improved control measures.

AB - The continued endemicity of foot and mouth disease virus (FMDV) in East Africa has significant implications for livestock production and poverty reduction, yet its complex epidemiology in endemic settings remains poorly understood. Identifying FMDV dispersal routes and drivers of transmission is key to improved control strategies. Environmental heterogeneity and anthropogenic drivers (e.g., demand for animal products) can impact viral spread by influencing host movements. Here, we utilized FMDV serotype O VP1 genetic sequences and corresponding spatiotemporal data in order to (i) infer the recent dispersal history, and (II) investigate the impact of external factors (cattle density, human population density, proximity to livestock markets, and drought) on dispersal velocity, location, and direction of FMDV serotype O in East Africa. We identified statistical evidence of long-distance transmission events, and we found that FMDV serotype O tends to remain circulating in areas of high cattle density, high human population density, and in close proximity to livestock markets. The latter two findings highlight the influence of anthropogenic factors on FMDV serotype O spread in this region. These findings contribute to the understanding of FMDV epidemiology in East Africa and can help guide improved control measures.

KW - Bayesian inference

KW - disease ecology

KW - environmental factors

KW - landscape phylogeography

KW - molecular epidemiology

KW - spatial analysis

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ER -

Phylogeographic analysis of foot-and-mouth disease virus serotype O dispersal and associated drivers in East Africa

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

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