Phylogenomics and evolution of secondary metabolism in plant-associated fungi

Joseph W. Spatafora, Kathryn E. Bushley

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


Fungi produce a myriad of secondary metabolites, compounds that are not required for basic cellular processes, but are thought to be central to ecological functions. Genomic sequencing of fungi has revealed a greater diversity of secondary metabolism than previously realized, including novel taxonomic distributions of known compounds and uncharacterized gene clusters in well-studied organisms. Here we provide an overview of the major groups of metabolites, their ecological functions, the genetic systems that produce them, and the patterns and processes associated with evolutionary diversification of secondary metabolism in plant-associated filamentous ascomycetes.

Original languageEnglish (US)
Pages (from-to)37-44
Number of pages8
JournalCurrent Opinion in Plant Biology
StatePublished - Aug 1 2015

Bibliographical note

Funding Information:
This material is based upon work supported by the National Science Foundation under Grant No. DEB-1258162 . Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation. The authors thank Dr. Kerry McPhail for assistance with preparation of Figure 1 .

Publisher Copyright:
© 2015 Elsevier Ltd.

Copyright 2015 Elsevier B.V., All rights reserved.


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