Phylogenetic and physical analysis of the 5′ leader RNA sequences of avian retroviruses

Perry B Hackett; Mark W. Dalton; Darrin P. Johnson; Robert B. Peterson

doi:10.1093/nar/19.24.6929

Phylogenetic and physical analysis of the 5′ leader RNA sequences of avian retroviruses

Perry B Hackett
, Mark W. Dalton
, Darrin P. Johnson
, Robert B. Peterson

Genetics, Cell Biology and Development (CBS)

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

A study of the secondary structures of the 5′-leader RNA sequences of avian leukosis/sarcoma viruses was conducted using phylogenetic sequence alignment, theoretical structures calculated from base-pairing interactions involving the calculated minimal ΔG values, and RNaseTI sensltivitiy. The results suggest that all of the avian retroviral RNA leaders may be able to adopt similar conformations. Open reading frames in the leader RNAs may be positioned to facilitate viral activities such as translation and packaging of the genomic RNA Into virus particles.

Original language	English (US)
Pages (from-to)	6929-6934
Number of pages	6
Journal	Nucleic acids research
Volume	19
Issue number	24
DOIs	https://doi.org/10.1093/nar/19.24.6929
State	Published - Dec 25 1991

Bibliographical note

Funding Information:
We thank M. Zuker, C. Hensel, A. Moustakas, and T. Sonstegard for discussions and reviewing the manuscript and an anonymous reviewer for suggestions. This work was supported by NIH grant CA 43881 and ACS grant INC/NP-790.

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title = "Phylogenetic and physical analysis of the 5′ leader RNA sequences of avian retroviruses",

abstract = "A study of the secondary structures of the 5′-leader RNA sequences of avian leukosis/sarcoma viruses was conducted using phylogenetic sequence alignment, theoretical structures calculated from base-pairing interactions involving the calculated minimal ΔG values, and RNaseTI sensltivitiy. The results suggest that all of the avian retroviral RNA leaders may be able to adopt similar conformations. Open reading frames in the leader RNAs may be positioned to facilitate viral activities such as translation and packaging of the genomic RNA Into virus particles.",

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note = "Funding Information: We thank M. Zuker, C. Hensel, A. Moustakas, and T. Sonstegard for discussions and reviewing the manuscript and an anonymous reviewer for suggestions. This work was supported by NIH grant CA 43881 and ACS grant INC/NP-790.",

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AU - Dalton, Mark W.

AU - Johnson, Darrin P.

AU - Peterson, Robert B.

N1 - Funding Information: We thank M. Zuker, C. Hensel, A. Moustakas, and T. Sonstegard for discussions and reviewing the manuscript and an anonymous reviewer for suggestions. This work was supported by NIH grant CA 43881 and ACS grant INC/NP-790.

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AB - A study of the secondary structures of the 5′-leader RNA sequences of avian leukosis/sarcoma viruses was conducted using phylogenetic sequence alignment, theoretical structures calculated from base-pairing interactions involving the calculated minimal ΔG values, and RNaseTI sensltivitiy. The results suggest that all of the avian retroviral RNA leaders may be able to adopt similar conformations. Open reading frames in the leader RNAs may be positioned to facilitate viral activities such as translation and packaging of the genomic RNA Into virus particles.

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JO - Nucleic acids research

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IS - 24

ER -

Phylogenetic and physical analysis of the 5′ leader RNA sequences of avian retroviruses

Abstract

Bibliographical note

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