Abstract
A study of the secondary structures of the 5′-leader RNA sequences of avian leukosis/sarcoma viruses was conducted using phylogenetic sequence alignment, theoretical structures calculated from base-pairing interactions involving the calculated minimal ΔG values, and RNaseTI sensltivitiy. The results suggest that all of the avian retroviral RNA leaders may be able to adopt similar conformations. Open reading frames in the leader RNAs may be positioned to facilitate viral activities such as translation and packaging of the genomic RNA Into virus particles.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 6929-6934 |
| Number of pages | 6 |
| Journal | Nucleic acids research |
| Volume | 19 |
| Issue number | 24 |
| DOIs | |
| State | Published - Dec 25 1991 |
Bibliographical note
Funding Information:We thank M. Zuker, C. Hensel, A. Moustakas, and T. Sonstegard for discussions and reviewing the manuscript and an anonymous reviewer for suggestions. This work was supported by NIH grant CA 43881 and ACS grant INC/NP-790.
