Phylogenetic and physical analysis of the 5′ leader RNA sequences of avian retroviruses

Perry B Hackett, Mark W. Dalton, Darrin P. Johnson, Robert B. Peterson

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


A study of the secondary structures of the 5′-leader RNA sequences of avian leukosis/sarcoma viruses was conducted using phylogenetic sequence alignment, theoretical structures calculated from base-pairing interactions involving the calculated minimal ΔG values, and RNaseTI sensltivitiy. The results suggest that all of the avian retroviral RNA leaders may be able to adopt similar conformations. Open reading frames in the leader RNAs may be positioned to facilitate viral activities such as translation and packaging of the genomic RNA Into virus particles.

Original languageEnglish (US)
Pages (from-to)6929-6934
Number of pages6
JournalNucleic acids research
Issue number24
StatePublished - Dec 25 1991

Bibliographical note

Funding Information:
We thank M. Zuker, C. Hensel, A. Moustakas, and T. Sonstegard for discussions and reviewing the manuscript and an anonymous reviewer for suggestions. This work was supported by NIH grant CA 43881 and ACS grant INC/NP-790.


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