Photon migration simulator for fluorescence tomography

Carlos Pardo-Martín, Thomas Pengo, Arrate Muñoz-Barrutia, Carlos Ortiz-de-Solorzano

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Analytically predicting photon paths in real -high scattering- anisotropic tissues is extremely complex, due to the significant random scattering events that photons suffer as they traverse the tissue, especially at boundaries between areas with different optical properties. An statistically correct optical and anatomical model of photon trajectories inside laboratory animals will therefore improve considerably our understanding about how light diffuses within the animals, and therefore help us designing efficient experimental setups and reconstruction algorithms for fluorescence mediated tomography (FMT). Here, we present new simulations of photon propagation and fluorescence emission in anisotropic media using realistic models of laboratory animals and a Monte Carlo (MC) based approach. We compare the MC simulation results with an approximation of the solution of the diffusion equation using finite differences and discuss the different behaviour of the two methods.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2008 - Physics of Medical Imaging
DOIs
StatePublished - May 14 2008
EventMedical Imaging 2008 - Physics of Medical Imaging - San Diego, CA, United States
Duration: Feb 18 2008Feb 21 2008

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6913
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2008 - Physics of Medical Imaging
CountryUnited States
CitySan Diego, CA
Period2/18/082/21/08

Keywords

  • ALG
  • MICRO
  • OPT
  • OT
  • PHT
  • SIM

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