TY - GEN
T1 - Photon migration simulator for fluorescence tomography
AU - Pardo-Martín, Carlos
AU - Pengo, Thomas
AU - Muñoz-Barrutia, Arrate
AU - Ortiz-de-Solorzano, Carlos
PY - 2008
Y1 - 2008
N2 - Analytically predicting photon paths in real -high scattering- anisotropic tissues is extremely complex, due to the significant random scattering events that photons suffer as they traverse the tissue, especially at boundaries between areas with different optical properties. An statistically correct optical and anatomical model of photon trajectories inside laboratory animals will therefore improve considerably our understanding about how light diffuses within the animals, and therefore help us designing efficient experimental setups and reconstruction algorithms for fluorescence mediated tomography (FMT). Here, we present new simulations of photon propagation and fluorescence emission in anisotropic media using realistic models of laboratory animals and a Monte Carlo (MC) based approach. We compare the MC simulation results with an approximation of the solution of the diffusion equation using finite differences and discuss the different behaviour of the two methods.
AB - Analytically predicting photon paths in real -high scattering- anisotropic tissues is extremely complex, due to the significant random scattering events that photons suffer as they traverse the tissue, especially at boundaries between areas with different optical properties. An statistically correct optical and anatomical model of photon trajectories inside laboratory animals will therefore improve considerably our understanding about how light diffuses within the animals, and therefore help us designing efficient experimental setups and reconstruction algorithms for fluorescence mediated tomography (FMT). Here, we present new simulations of photon propagation and fluorescence emission in anisotropic media using realistic models of laboratory animals and a Monte Carlo (MC) based approach. We compare the MC simulation results with an approximation of the solution of the diffusion equation using finite differences and discuss the different behaviour of the two methods.
KW - ALG
KW - MICRO
KW - OPT
KW - OT
KW - PHT
KW - SIM
UR - http://www.scopus.com/inward/record.url?scp=43149125460&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=43149125460&partnerID=8YFLogxK
U2 - 10.1117/12.770733
DO - 10.1117/12.770733
M3 - Conference contribution
AN - SCOPUS:43149125460
SN - 9780819470973
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Medical Imaging 2008 - Physics of Medical Imaging
T2 - Medical Imaging 2008 - Physics of Medical Imaging
Y2 - 18 February 2008 through 21 February 2008
ER -