Photodynamic therapy with fullerenes

Pawel Mroz, George P. Tegos, Hariprasad Gali, Tim Wharton, Tadeusz Sarna, Michael R. Hamblin

Research output: Contribution to journalReview article

185 Citations (Scopus)

Abstract

Fullerenes are a class of closed-cage nanomaterials made exclusively from carbon atoms. A great deal of attention has been focused on developing medical uses of these unique molecules especially when they are derivatized with functional groups to make them soluble and therefore able to interact with biological systems. Due to their extended π-conjugation they absorb visible light, have a high triplet yield and can generate reactive oxygen species upon illumination, suggesting a possible role of fullerenes in photodynamic therapy. Depending on the functional groups introduced into the molecule, fullerenes can effectively photoinactivate either or both pathogenic microbial cells and malignant cancer cells. The mechanism appears to involve superoxide anion as well as singlet oxygen, and under the right conditions fullerenes may have advantages over clinically applied photosensitizers for mediating photodynamic therapy of certain diseases.

Original languageEnglish (US)
Pages (from-to)1139-1149
Number of pages11
JournalPhotochemical and Photobiological Sciences
Volume6
Issue number11
DOIs
StatePublished - Nov 15 2007

Fingerprint

Fullerenes
Photodynamic therapy
fullerenes
therapy
Functional groups
Singlet Oxygen
Molecules
Photosensitizing Agents
inorganic peroxides
oxygen
Biological systems
conjugation
Nanostructured materials
Superoxides
molecules
Reactive Oxygen Species
Carbon
Lighting
cancer
illumination

Cite this

Mroz, P., Tegos, G. P., Gali, H., Wharton, T., Sarna, T., & Hamblin, M. R. (2007). Photodynamic therapy with fullerenes. Photochemical and Photobiological Sciences, 6(11), 1139-1149. https://doi.org/10.1039/b711141j

Photodynamic therapy with fullerenes. / Mroz, Pawel; Tegos, George P.; Gali, Hariprasad; Wharton, Tim; Sarna, Tadeusz; Hamblin, Michael R.

In: Photochemical and Photobiological Sciences, Vol. 6, No. 11, 15.11.2007, p. 1139-1149.

Research output: Contribution to journalReview article

Mroz, P, Tegos, GP, Gali, H, Wharton, T, Sarna, T & Hamblin, MR 2007, 'Photodynamic therapy with fullerenes', Photochemical and Photobiological Sciences, vol. 6, no. 11, pp. 1139-1149. https://doi.org/10.1039/b711141j
Mroz P, Tegos GP, Gali H, Wharton T, Sarna T, Hamblin MR. Photodynamic therapy with fullerenes. Photochemical and Photobiological Sciences. 2007 Nov 15;6(11):1139-1149. https://doi.org/10.1039/b711141j
Mroz, Pawel ; Tegos, George P. ; Gali, Hariprasad ; Wharton, Tim ; Sarna, Tadeusz ; Hamblin, Michael R. / Photodynamic therapy with fullerenes. In: Photochemical and Photobiological Sciences. 2007 ; Vol. 6, No. 11. pp. 1139-1149.
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