Objective: To demonstrate the feasibility of adjuvant intraoperative photodynamic therapy in the treatment of large, infiltrating, recurrent carcinomas of the head and neck. Design: A nonrandomized trial involving 5 patients treated with intraoperative adjuvant photodynamic therapy with 29- month follow-up. Setting: A tertiary care referral center in a private practice setting. Patients: Five patients with massive, recurrent, infiltrating squamous cell carcinomas of the head and neck and skull base. Intervention: Photodynamic therapy was used as an adjuvant intraoperative treatment after resection of tumors. Main Outcome Measure: Time of survival after treatment without recurrence of disease. Results: Four of the 5 patients have remained free of recurrent disease without complications up to 24 months after treatment. Conclusion: Adjuvant intraoperative photodynamic therapy may improve cure rates in patients with recurrent head and neck malignancies by providing larger tumor-free margins of resection, while preserving normal structures.
|Original language||English (US)|
|Number of pages||5|
|Journal||Archives of Otolaryngology - Head and Neck Surgery|
|State||Published - Nov 1996|