Photodynamic therapy as an adjuvant intraoperative treatment of recurrent head and neck carcinomas

Merrill A. Bid

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Objective: To demonstrate the feasibility of adjuvant intraoperative photodynamic therapy in the treatment of large, infiltrating, recurrent carcinomas of the head and neck. Design: A nonrandomized trial involving 5 patients treated with intraoperative adjuvant photodynamic therapy with 29- month follow-up. Setting: A tertiary care referral center in a private practice setting. Patients: Five patients with massive, recurrent, infiltrating squamous cell carcinomas of the head and neck and skull base. Intervention: Photodynamic therapy was used as an adjuvant intraoperative treatment after resection of tumors. Main Outcome Measure: Time of survival after treatment without recurrence of disease. Results: Four of the 5 patients have remained free of recurrent disease without complications up to 24 months after treatment. Conclusion: Adjuvant intraoperative photodynamic therapy may improve cure rates in patients with recurrent head and neck malignancies by providing larger tumor-free margins of resection, while preserving normal structures.

Original languageEnglish (US)
Pages (from-to)1261-1265
Number of pages5
JournalArchives of Otolaryngology - Head and Neck Surgery
Volume122
Issue number11
DOIs
StatePublished - Nov 1996

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