Abstract
Photodynamic therapy (PDT) uses non-toxic photosensitizers and harmless visible light in combination with oxygen to produce cytotoxic reactive oxygen species that kill malignant cells by apoptosis and/or necrosis, shut down the tumour microvasculature and stimulate the host immune system. In contrast to surgery, radiotherapy and chemotherapy that are mostly immunosuppressive, PDT causes acute inflammation, expression of heat-shock proteins, invasion and infiltration of the tumour by leukocytes, and might increase the presentation of tumour-derived antigens to T cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 535-545 |
| Number of pages | 11 |
| Journal | Nature Reviews Cancer |
| Volume | 6 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 1 2006 |
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Photodynamic therapy and anti-tumour immunity. / Castano, Ana P.; Mroz, Pawel; Hamblin, Michael R.
In: Nature Reviews Cancer, Vol. 6, No. 7, 01.07.2006, p. 535-545.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Photodynamic therapy and anti-tumour immunity
AU - Castano, Ana P.
AU - Mroz, Pawel
AU - Hamblin, Michael R.
PY - 2006/7/1
Y1 - 2006/7/1
N2 - Photodynamic therapy (PDT) uses non-toxic photosensitizers and harmless visible light in combination with oxygen to produce cytotoxic reactive oxygen species that kill malignant cells by apoptosis and/or necrosis, shut down the tumour microvasculature and stimulate the host immune system. In contrast to surgery, radiotherapy and chemotherapy that are mostly immunosuppressive, PDT causes acute inflammation, expression of heat-shock proteins, invasion and infiltration of the tumour by leukocytes, and might increase the presentation of tumour-derived antigens to T cells.
AB - Photodynamic therapy (PDT) uses non-toxic photosensitizers and harmless visible light in combination with oxygen to produce cytotoxic reactive oxygen species that kill malignant cells by apoptosis and/or necrosis, shut down the tumour microvasculature and stimulate the host immune system. In contrast to surgery, radiotherapy and chemotherapy that are mostly immunosuppressive, PDT causes acute inflammation, expression of heat-shock proteins, invasion and infiltration of the tumour by leukocytes, and might increase the presentation of tumour-derived antigens to T cells.
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UR - http://www.scopus.com/inward/citedby.url?scp=33745537921&partnerID=8YFLogxK
U2 - 10.1038/nrc1894
DO - 10.1038/nrc1894
M3 - Review article
VL - 6
SP - 535
EP - 545
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
SN - 1474-175X
IS - 7
ER -