Photodynamic therapy and anti-tumour immunity

Ana P. Castano, Pawel Mroz, Michael R. Hamblin

Research output: Contribution to journalReview article

1230 Citations (Scopus)

Abstract

Photodynamic therapy (PDT) uses non-toxic photosensitizers and harmless visible light in combination with oxygen to produce cytotoxic reactive oxygen species that kill malignant cells by apoptosis and/or necrosis, shut down the tumour microvasculature and stimulate the host immune system. In contrast to surgery, radiotherapy and chemotherapy that are mostly immunosuppressive, PDT causes acute inflammation, expression of heat-shock proteins, invasion and infiltration of the tumour by leukocytes, and might increase the presentation of tumour-derived antigens to T cells.

Original languageEnglish (US)
Pages (from-to)535-545
Number of pages11
JournalNature Reviews Cancer
Volume6
Issue number7
DOIs
StatePublished - Jul 1 2006

Fingerprint

Photochemotherapy
Immunity
Photosensitizing Agents
Neoplasm Antigens
Immunosuppressive Agents
Heat-Shock Proteins
Microvessels
Immune System
Reactive Oxygen Species
Neoplasms
Leukocytes
Necrosis
Radiotherapy
Apoptosis
Oxygen
Inflammation
T-Lymphocytes
Light
Drug Therapy

Cite this

Photodynamic therapy and anti-tumour immunity. / Castano, Ana P.; Mroz, Pawel; Hamblin, Michael R.

In: Nature Reviews Cancer, Vol. 6, No. 7, 01.07.2006, p. 535-545.

Research output: Contribution to journalReview article

Castano, Ana P. ; Mroz, Pawel ; Hamblin, Michael R. / Photodynamic therapy and anti-tumour immunity. In: Nature Reviews Cancer. 2006 ; Vol. 6, No. 7. pp. 535-545.
@article{7a18a38fc1fb46fd9be123dad14df93b,
title = "Photodynamic therapy and anti-tumour immunity",
abstract = "Photodynamic therapy (PDT) uses non-toxic photosensitizers and harmless visible light in combination with oxygen to produce cytotoxic reactive oxygen species that kill malignant cells by apoptosis and/or necrosis, shut down the tumour microvasculature and stimulate the host immune system. In contrast to surgery, radiotherapy and chemotherapy that are mostly immunosuppressive, PDT causes acute inflammation, expression of heat-shock proteins, invasion and infiltration of the tumour by leukocytes, and might increase the presentation of tumour-derived antigens to T cells.",
author = "Castano, {Ana P.} and Pawel Mroz and Hamblin, {Michael R.}",
year = "2006",
month = "7",
day = "1",
doi = "10.1038/nrc1894",
language = "English (US)",
volume = "6",
pages = "535--545",
journal = "Nature Reviews Cancer",
issn = "1474-175X",
publisher = "Nature Publishing Group",
number = "7",

}

TY - JOUR

T1 - Photodynamic therapy and anti-tumour immunity

AU - Castano, Ana P.

AU - Mroz, Pawel

AU - Hamblin, Michael R.

PY - 2006/7/1

Y1 - 2006/7/1

N2 - Photodynamic therapy (PDT) uses non-toxic photosensitizers and harmless visible light in combination with oxygen to produce cytotoxic reactive oxygen species that kill malignant cells by apoptosis and/or necrosis, shut down the tumour microvasculature and stimulate the host immune system. In contrast to surgery, radiotherapy and chemotherapy that are mostly immunosuppressive, PDT causes acute inflammation, expression of heat-shock proteins, invasion and infiltration of the tumour by leukocytes, and might increase the presentation of tumour-derived antigens to T cells.

AB - Photodynamic therapy (PDT) uses non-toxic photosensitizers and harmless visible light in combination with oxygen to produce cytotoxic reactive oxygen species that kill malignant cells by apoptosis and/or necrosis, shut down the tumour microvasculature and stimulate the host immune system. In contrast to surgery, radiotherapy and chemotherapy that are mostly immunosuppressive, PDT causes acute inflammation, expression of heat-shock proteins, invasion and infiltration of the tumour by leukocytes, and might increase the presentation of tumour-derived antigens to T cells.

UR - http://www.scopus.com/inward/record.url?scp=33745537921&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745537921&partnerID=8YFLogxK

U2 - 10.1038/nrc1894

DO - 10.1038/nrc1894

M3 - Review article

VL - 6

SP - 535

EP - 545

JO - Nature Reviews Cancer

JF - Nature Reviews Cancer

SN - 1474-175X

IS - 7

ER -