Photoactivation of the nitric oxide donor SIN-1

Thomas Ullrich, Stefanie Oberle, Aida Abate, Henning Schröder

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

This study investigates whether nitric oxide (NO) release from linsidomine (SIN-1), the active metabolite of the antianginal drug molsidomine, is light sensitive. A 9-h irradiation with polychromatic visible light increased the formation of nitrite (NO index metabolite) from SIN-1 (1 mM) by 61% as compared to control samples incubated in the dark. Under the same conditions (9-h irradiation) the concentration of oxygen decreased to 2% of control. However, oxygen consumption was substantially reduced when light was excluded (35% recovery after 9 h). These results show that irradiation with visible light markedly enhances the oxygen-dependent NO release from SIN-1. Thus, sydnonimines appear to be suitable model compounds for the development of photoactivatable NO donors.

Original languageEnglish (US)
Pages (from-to)66-68
Number of pages3
JournalFEBS Letters
Volume406
Issue number1-2
DOIs
StatePublished - Apr 7 1997

Bibliographical note

Funding Information:
This work was supported by the Deutsche Forschungsgemeinschaft (Schr 298/8-1). We would like to thank Martina Heidler for assistance in the preparation of the manuscript and Dr. Jens Lange, MLU Department of Physics, for helpful discussions.

Keywords

  • Linsidomine
  • Nitric oxide
  • Nitrite
  • Photoactivation
  • SIN-1
  • Sodium nitroprusside

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