Phosphorylation of serine 51 regulates the interaction of human DNA ligase I with replication factor C and its participation in DNA replication and repair

Zhimin Peng; Zhongping Liao; Barbara Dziegielewska; Yoshi Matsumoto; Stefani Thomas; Yunhu Wan; Austin Yang; Alan E. Tomkinson

doi:10.1074/jbc.M112.383570

Phosphorylation of serine 51 regulates the interaction of human DNA ligase I with replication factor C and its participation in DNA replication and repair

Zhimin Peng, Zhongping Liao, Barbara Dziegielewska, Yoshi Matsumoto, Stefani Thomas, Yunhu Wan, Austin Yang, Alan E. Tomkinson

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Background: Phosphorylation of human DNA ligase I (hLigI) regulates its participation in DNA replication and repair. Results: Identification of a single phosphorylation site that regulates the interaction of hLigI with replication factor C (RFC). Conclusion: Interaction between hLigI and RFC is critical for DNA replication and repair. Significance: We provide insights into the mechanism by which a single phosphorylation site regulates the cellular functions of hLigI.

Original language	English (US)
Pages (from-to)	36711-36719
Number of pages	9
Journal	Journal of Biological Chemistry
Volume	287
Issue number	44
DOIs	https://doi.org/10.1074/jbc.M112.383570
State	Published - Oct 26 2012
Externally published	Yes

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title = "Phosphorylation of serine 51 regulates the interaction of human DNA ligase I with replication factor C and its participation in DNA replication and repair",

abstract = "Background: Phosphorylation of human DNA ligase I (hLigI) regulates its participation in DNA replication and repair. Results: Identification of a single phosphorylation site that regulates the interaction of hLigI with replication factor C (RFC). Conclusion: Interaction between hLigI and RFC is critical for DNA replication and repair. Significance: We provide insights into the mechanism by which a single phosphorylation site regulates the cellular functions of hLigI.",

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T1 - Phosphorylation of serine 51 regulates the interaction of human DNA ligase I with replication factor C and its participation in DNA replication and repair

AU - Peng, Zhimin

AU - Liao, Zhongping

AU - Dziegielewska, Barbara

AU - Matsumoto, Yoshi

AU - Thomas, Stefani

AU - Wan, Yunhu

AU - Yang, Austin

AU - Tomkinson, Alan E.

PY - 2012/10/26

Y1 - 2012/10/26

N2 - Background: Phosphorylation of human DNA ligase I (hLigI) regulates its participation in DNA replication and repair. Results: Identification of a single phosphorylation site that regulates the interaction of hLigI with replication factor C (RFC). Conclusion: Interaction between hLigI and RFC is critical for DNA replication and repair. Significance: We provide insights into the mechanism by which a single phosphorylation site regulates the cellular functions of hLigI.

AB - Background: Phosphorylation of human DNA ligase I (hLigI) regulates its participation in DNA replication and repair. Results: Identification of a single phosphorylation site that regulates the interaction of hLigI with replication factor C (RFC). Conclusion: Interaction between hLigI and RFC is critical for DNA replication and repair. Significance: We provide insights into the mechanism by which a single phosphorylation site regulates the cellular functions of hLigI.

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JO - Journal of Biological Chemistry

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IS - 44

ER -

Phosphorylation of serine 51 regulates the interaction of human DNA ligase I with replication factor C and its participation in DNA replication and repair

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