Abstract
The sensitivity to regulation of proteins undergoing covalent modification can be greatly increased when the substrates saturate the converter enzymes. This phenomenon, termed zero-order ultrasensitivity, has been found to occur in the reversible phosphorylation of isocitrate dehydrogenase. The possibility that this enhanced sensitivity is a common feature of covalent regulatory systems is discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 286-290 |
| Number of pages | 5 |
| Journal | Nature |
| Volume | 305 |
| Issue number | 5932 |
| DOIs | |
| State | Published - 1983 |
Fingerprint
Dive into the research topics of 'Phosphorylation of isocitrate dehydrogenase as a demonstration of enhanced sensitivity in covalent regulation'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS