Phosphorylation of isocitrate dehydrogenase as a demonstration of enhanced sensitivity in covalent regulation

David C. Laporte, Daniel E. Koshland

Research output: Contribution to journalArticlepeer-review

119 Scopus citations

Abstract

The sensitivity to regulation of proteins undergoing covalent modification can be greatly increased when the substrates saturate the converter enzymes. This phenomenon, termed zero-order ultrasensitivity, has been found to occur in the reversible phosphorylation of isocitrate dehydrogenase. The possibility that this enhanced sensitivity is a common feature of covalent regulatory systems is discussed.

Original languageEnglish (US)
Pages (from-to)286-290
Number of pages5
JournalNature
Volume305
Issue number5932
DOIs
StatePublished - Dec 1 1983

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