Phosphorylation in two discrete tau domains regulates a stepwise process leading to postsynaptic dysfunction

Keyphrases

• Phosphorylation 100%
• Delocalization 100%
• Dendritic Spines 100%
• Stepwise Procedure 100%
• Spontaneous Excitatory Postsynaptic Current (sEPSC) 100%
• Phosphorylation Sites 33%
• Glycogen Synthase 33%
• Proline-rich Region 33%
• Cyclin-dependent Kinase 5 (Cdk5) 33%
• Differential Phosphorylation 33%
• Imaging Techniques 16%
• AMPA Receptor (AMPAR) 16%
• Synaptic Dysfunction 16%
• Spine 16%
• Alzheimer's Dementia 16%
• Neurodegenerative Diseases 16%
• Tau Phosphorylation 16%
• Frontotemporal Dementia 16%
• C-terminus 16%
• N-terminal Domain 16%
• Non-overlapping 16%
• Cultured Hippocampal Neurons 16%
• Binding Partners 16%
• Tau Protein 16%
• Electrophysiological Techniques 16%
• Sequential Process 16%
• P301L 16%
• Proline-directed Kinase 16%
• Projection Domain 16%
• Microtubule-binding Domain 16%
• Tau Hyperphosphorylation 16%

Neuroscience

• Dendritic Spine 100%
• C-Terminus 66%
• Proline 50%
• Amino Terminal Sequence 50%
• Cyclin Dependent Kinase 5 33%
• Glycogen Synthase Kinase 33%
• Imaging Technique 16%
• Neurodegenerative Disorder 16%
• Microtubules 16%
• Electrophysiological Technique 16%
• Frontotemporal Dementia 16%
• Tau Protein 16%
• AMPA Receptor 16%
• Hyperphosphorylation 16%
• Vertebral Column 16%
• Alzheimer's Disease 16%

Biochemistry, Genetics and Molecular Biology

• Tau 100%
• Dendritic Spine 50%
• C-Terminus 33%
• N-Terminus 25%
• Proline 25%
• Glycogen Synthase Kinase 16%
• Cyclin-Dependent Kinase 5 16%
• Binding Domain 8%
• Hyperphosphorylation 8%
• Electrophysiological Procedures 8%
• AMPA Receptor 8%
• Tau Protein 8%